concept

ARF6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

1Analyses

43Outgoing

10Incoming

1Experiments

1Debates

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💡 Concept Info

Name	ARF6
Key Genes/Proteins	AD RISK GENES, ALZHEIMER, ALZHEIMER'S DISEASE, Ampa Receptor, AMYLOID, AMYLOID-BETA
Related Diseases	Als, ALS, Alzheimer
Related Pathways	ABCA1 endosomal retention, autophagy pathway

Pathway Diagram

graph TD
    ARF6["ARF6"]
    ARF6 -->|"interacts"| VE_cadherin["VE-cadherin"]
    ARF6 -->|"interacts"| CDH5["CDH5"]
    ARF6 -->|"involved_in"| Cdh5_Trafficking["Cdh5 Trafficking"]
    ARF6 -->|"involved_in"| VE_cadherin_Trafficking["VE-cadherin Trafficking"]
    ARF6 -->|"interacts"| ALS["ALS"]
    ARF6 -->|"interacts"| Als["Als"]
    ARF6 -->|"regulates"| Alzheimer["Alzheimer"]
    VE_cadherin -->|"interacts"| ARF6
    REELIN["REELIN"] -->|"interacts"| ARF6
    SYNAPSE["SYNAPSE"] -->|"regulates"| ARF6
    GENES["GENES"] -->|"regulates"| ARF6
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| ARF6
    AD_RISK_GENES["AD RISK GENES"] -->|"regulates"| ARF6
    BIN1["BIN1"] -->|"regulates"| ARF6

Outgoing (43)

Target	Relation	Type	Str
Cdh5 Trafficking	involved_in	process	0.90
CDH5	interacts_with	protein	0.90
VE-cadherin	interacts_with	protein	0.90
Ve-Cadherin Trafficking	involved_in	process	0.85
VE-cadherin trafficking	regulates	process	0.85
CDH5	regulates	gene	0.85
junctional remodeling	involved_in	process	0.85
VE-cadherin Trafficking	involved_in	process	0.80
ABCA1 endosomal retention	modulates	mechanism	0.70
ALS	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	associated_with	disease	0.65
ALS	interacts_with	disease	0.65
MAPK signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
ALZHEIMER	inhibits	gene	0.60
ENDOSOMES	inhibits	gene	0.60
APP	associated_with	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
RAC1	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
RHOA	associated_with	gene	0.60
REELIN	interacts_with	gene	0.60
Raf	interacts_with	protein	0.60
App	interacts_with	protein	0.60
neurons	expressed_in	cell_type	0.60
Endothelial	interacts_with	cell_type	0.60
AMYLOID	inhibits	gene	0.60
ATG	activates	gene	0.60
DCTN1	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Raf	regulates	protein	0.60
Ampa Receptor	regulates	protein	0.60
ALZHEIMER	regulates	gene	0.60
BIN1	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
RAB11	associated_with	gene	0.60
Endothelial Cell	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
CDH5	interacts_with	protein	0.85
VE-cadherin	interacts_with	protein	0.85
VE-cadherin	participates_in	protein	0.80
SYNAPSE	regulates	gene	0.60
GENES	regulates	gene	0.60
RAB11	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
AD RISK GENES	regulates	gene	0.60
BIN1	regulates	gene	0.60
REELIN	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retenti

molecular biology | 2026-04-24 | 6 hypotheses Top: 0.741

Experiments (1)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
ARF6 and exocyst complex role in VE-cadherin trafficking	exploratory		0.800	0.00	lymphatic endothelial cells	proposed	N/A

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

Does APOE4's reduced lipid-binding directly modulate SREBP2-SCAP complex retenti

closed · Rounds: 4 · Score: 0.58 · 2026-04-24

Related Research

Hypotheses and analyses mentioning ARF6 in their description or question text

No additional research found