concept

ARF6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about ARF6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

53Connections

0Hypotheses

0Analyses

43Outgoing

10Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	ARF6
Key Genes/Proteins	VE-cadherin, CDH5, AND
Related Diseases	ALS, Als, Alzheimer

Wiki Pages (9)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    ARF6["ARF6"]
    ARF6 -->|"interacts"| VE_cadherin["VE-cadherin"]
    ARF6 -->|"interacts"| CDH5["CDH5"]
    ARF6 -->|"involved_in"| Cdh5_Trafficking["Cdh5 Trafficking"]
    ARF6 -->|"involved_in"| VE_cadherin_Trafficking["VE-cadherin Trafficking"]
    ARF6 -->|"interacts"| ALS["ALS"]
    ARF6 -->|"interacts"| Als["Als"]
    ARF6 -->|"regulates"| Alzheimer["Alzheimer"]
    VE_cadherin -->|"interacts"| ARF6
    REELIN["REELIN"] -->|"interacts"| ARF6
    SYNAPSE["SYNAPSE"] -->|"regulates"| ARF6
    GENES["GENES"] -->|"regulates"| ARF6
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| ARF6
    AD_RISK_GENES["AD RISK GENES"] -->|"regulates"| ARF6
    BIN1["BIN1"] -->|"regulates"| ARF6

Outgoing (43)

Target	Relation	Type	Str
VE-cadherin	interacts_with	protein	0.90
CDH5	interacts_with	protein	0.90
Cdh5 Trafficking	involved_in	process	0.90
Ve-Cadherin Trafficking	involved_in	process	0.85
CDH5	regulates	gene	0.85
junctional remodeling	involved_in	process	0.85
VE-cadherin Trafficking	involved_in	process	0.80
ALS	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Alzheimer	regulates	disease	0.65
Als	associated_with	disease	0.65
Alzheimer	inhibits	disease	0.65
ALS	associated_with	disease	0.65
AND	interacts_with	gene	0.60
Endothelial	interacts_with	cell_type	0.60
ALZHEIMER	regulates	gene	0.60
BIN1	regulates	gene	0.60
SYNAPSE	regulates	gene	0.60
RAB11	associated_with	gene	0.60
AMYLOID	inhibits	gene	0.60
ALZHEIMER	inhibits	gene	0.60
ENDOSOMES	inhibits	gene	0.60
APP	associated_with	gene	0.60
AMYLOID-BETA	inhibits	gene	0.60
RAC1	associated_with	gene	0.60
CDC42	associated_with	gene	0.60
RHOA	associated_with	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
REELIN	interacts_with	gene	0.60
Raf	interacts_with	protein	0.60
App	interacts_with	protein	0.60
Raf	regulates	protein	0.60
Ampa Receptor	regulates	protein	0.60
ATG	activates	gene	0.60
DCTN1	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3B	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MAPK signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
neurons	expressed_in	cell_type	0.60
Endothelial Cell	expressed_in	cell_type	0.55

Incoming (10)

Source	Relation	Type	Str
VE-cadherin	interacts_with	protein	0.85
CDH5	interacts_with	protein	0.85
VE-cadherin	participates_in	protein	0.80
REELIN	interacts_with	gene	0.60
SYNAPSE	regulates	gene	0.60
GENES	regulates	gene	0.60
RAB11	associated_with	gene	0.60
ALZHEIMER	regulates	gene	0.60
AD RISK GENES	regulates	gene	0.60
BIN1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

ARF6

Understanding Entity Pages

Wiki Pages (9)

DOCK1 Gene

ARF3 Gene

SND1 — Stonin 1

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LDLRAP1 — Low Density Lipoprotein Receptor Adaptor Protein 1

ARF5 Gene

git1