Scientific World Model

The world's most comprehensive mechanistic knowledge base for neurodegenerative diseases.

17,471 pages — genes, proteins, mechanisms, therapeutics, and more

What is the Scientific World Model?

Our AI agents have synthesized 17,000+ wiki-style pages covering every major entity, mechanism, and therapeutic avenue in neurodegeneration research. Each page is automatically generated and continuously updated from the latest scientific literature, connecting genes like APOE and MAPT to pathways, proteins, and disease mechanisms.

This forms a living knowledge graph that powers our hypothesis generation, therapeutic target identification, and research gap analysis. Browse by entity type below or search for any gene, protein, mechanism, or drug.

All (17,471)🧬 gene (3,869)🔬 cell (3,397)🔬 protein (3,107)⚙️ mechanism (1,789)💊 therapeutic (1,028)🏢 company (643)🏥 disease (496)🧪 clinical (392)🏛️ institution (308)👤 researcher (214)💡 idea (200)↪️ redirect (185)📊 biomarker (182)🧫 experiment (161) general (151)🔧 technology (151) ai_tool (141) entity (113)
Showing 1–50 of 1,789 pages

⚙️ Sleep and Circadian Dysfunction in Alzheimer's DiseaseKG

mechanism · 8,066 words · 72 hyp60 ana60 exp

⚙️ Microglia CD8+ T Cell Recruitment -- Supplementary WW ContentKG

mechanism · 7,227 words · 55 hyp47 ana13 exp

⚙️ Parthanatos in NeurodegenerationKG

mechanism · 6,619 words · 278 hyp52 ana55 exp

⚙️ calcium-dysregulation-comparisonKG

mechanism · 6,468 words · 121 hyp62 ana6 exp

⚙️ Alpha-Synuclein PathologyKG

mechanism · 6,288 words · 11 hyp39 ana16 exp

⚙️ Myoclonus and Cortical Hyperexcitability in Corticobasal SyndromeKG

mechanism · 6,138 words · 9 hyp37 ana1 exp

⚙️ PD Combination Therapy MatrixKG

mechanism · 5,949 words · 65 hyp52 ana6 exp

⚙️ Alzheimer's Disease Mechanism IndexKG

mechanism · 5,834 words · 51 hyp47 ana56 exp

⚙️ Neuroresilience Mechanisms and EvidenceKG

mechanism · 5,775 words · 38 hyp40 ana29 exp

⚙️ Frontotemporal Dementia (FTD) Mechanistic PathwayKG

mechanism · 5,506 words · 37 hyp43 ana17 exp

⚙️ neuroinflammationKG

mechanism · 5,462 words · 232 hyp95 ana107 exp

⚙️ NRF2 Oxidative Stress PathwayKG

mechanism · 5,315 words · 41 hyp41 ana27 exp

⚙️ PD Cure RoadmapKG

mechanism · 5,171 words · 14 hyp34 ana11 exp

⚙️ TREM2 Mechanism HubKG

mechanism · 5,099 words · 181 hyp102 ana52 exp

⚙️ Neuroimmune Response in 4R-Tauopathies: Cross-Disease ComparisonKG

mechanism · 5,083 words · 35 hyp46 ana14 exp

⚙️ Mitochondrial Quality ControlKG

mechanism · 5,069 words · 67 hyp48 ana17 exp

⚙️ Astrocyte Reactivity MechanismKG

mechanism · 5,036 words · 136 hyp63 ana26 exp

⚙️ GSK-3β in NeurodegenerationKG

mechanism · 5,020 words · 283 hyp52 ana57 exp

⚙️ ALS Failed Approaches AnalysisKG

mechanism · 4,973 words · 8 hyp58 ana58 exp

⚙️ Mitochondrial Dysfunction in Parkinson's DiseaseKG

mechanism · 4,972 words · 46 hyp51 ana65 exp

⚙️ Circadian Rhythm in NeurodegenerationKG

mechanism · 4,939 words · 286 hyp59 ana71 exp

⚙️ Synucleinopathy MechanismKG

mechanism · 4,870 words · 11 hyp38 ana7 exp

⚙️ Energy Metabolism Dysfunction Comparison Across Neurodegenerative DiseasesKG

mechanism · 4,869 words · 38 hyp41 ana5 exp

⚙️ Autophagy MechanismsKG

mechanism · 4,866 words · 133 hyp63 ana16 exp

⚙️ Vesicle Trafficking Dysfunction in Corticobasal SyndromeKG

mechanism · 4,859 words · 18 hyp42 ana1 exp

⚙️ Tau Spreading MechanismKG

mechanism · 4,818 words · 22 hyp35 ana6 exp

⚙️ oxidative-stress-comparisonKG

mechanism · 4,814 words · 34 hyp39 ana23 exp

⚙️ Blood-Brain Barrier Dysfunction in NeurodegenerationKG

mechanism · 4,726 words · 331 hyp66 ana62 exp

⚙️ Neurotrophin Signaling Pathways in NeurodegenerationKG

mechanism · 4,695 words · 290 hyp57 ana57 exp

⚙️ Wnt Non-Canonical Signaling Pathways in NeurodegenerationKG

mechanism · 4,664 words · 293 hyp56 ana57 exp

⚙️ ftd-tdp-pathologyKG

mechanism · 4,657 words · 11 hyp54 ana25 exp

⚙️ amyloid-beta-metalloproteinasesKG

mechanism · 4,656 words · 181 hyp65 ana16 exp

⚙️ Mitophagy Pathway in NeurodegenerationKG

mechanism · 4,637 words · 301 hyp61 ana65 exp

⚙️ gabaergic-dysfunctionKG

mechanism · 4,621 words · 15 hyp37 ana8 exp

⚙️ TREM2 Microglial Signaling Pathway in NeurodegenerationKG

mechanism · 4,613 words · 329 hyp74 ana95 exp

⚙️ Axonal Transport Dysfunction Comparison Across Neurodegenerative DiseasesKG

mechanism · 4,604 words · 45 hyp47 ana11 exp

⚙️ dendritic-spinesKG

mechanism · 4,574 words · 6 hyp35 ana3 exp

⚙️ AI and Machine Learning in NeurodegenerationKG

mechanism · 4,541 words · 289 hyp57 ana58 exp

⚙️ Vitamin D Signaling Pathway in NeurodegenerationKG

mechanism · 4,520 words · 294 hyp57 ana57 exp

⚙️ Cerebellar FunctionKG

mechanism · 4,485 words · 10 hyp32 ana2 exp

⚙️ VEGF/Angiogenesis Pathway in NeurodegenerationKG

mechanism · 4,480 words · 287 hyp53 ana60 exp

⚙️ Blood-Brain Barrier Biology and Crossing StrategiesKG

mechanism · 4,474 words · 198 hyp64 ana12 exp

⚙️ Synaptic Vesicle Trafficking in Parkinson's DiseaseKG

mechanism · 4,417 words · 39 hyp53 ana61 exp

⚙️ Tau Strain Diversity and Conformational Templating in TauopathiesKG

mechanism · 4,415 words · 19 hyp36 ana8 exp

⚙️ GBA Pathway in Parkinson's DiseaseKG

mechanism · 4,381 words · 26 hyp49 ana75 exp

⚙️ psp-tauopathyKG

mechanism · 4,377 words · 18 hyp37 ana28 exp

⚙️ Epigenetic Dysregulation in NeurodegenerationKG

mechanism · 4,376 words · 320 hyp62 ana79 exp

⚙️ Infectious Triggers in Alzheimer's DiseaseKG

mechanism · 4,367 words · 75 hyp48 ana52 exp

⚙️ Mitochondrial Dysfunction in NeurodegenerationKG

mechanism · 4,363 words · 296 hyp59 ana62 exp

⚙️ Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HDKG

mechanism · 4,361 words · 54 hyp46 ana46 exp

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