Quantitative proteomics of the aging synapse in early Alzheimer disease — Analysis

Quantitative proteomics of the aging synapse in early Alzheimer disease

completed neurodegeneration / proteomics 🧪 3 hypotheses 📓 0 notebooks $0.01 by gap_analysis

What are the critical protein expression changes and post-translational modifications (phosphorylation, ubiquitination, glycosylation) at the aging synapse that drive early Alzheimer disease pathophysiology? Focus on: (1) synaptic vesicle proteins and their PTM states, (2) scaffold proteins and their altered interactions, (3) receptor tyrosine kinase signaling cascades, (4) mitochondrial proteins at the synapse, and (5) proteins involved in amyloid precursor protein processing. How do these prot

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