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Ubiquitin

wiki page Created: 2026-04-02 13:40:08 By: crosslink-migration Quality: 50% ✓ SciDEX ID: wiki-proteins-ubiquitin
Related Entities
UBIQUITIN
Metadata
slugproteins-ubiquitin
entity_typeprotein
kg_node_idUBIQUITIN
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (306)
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering65%
mentions🧪Circadian-Synchronized Proteostasis Enhancement65%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer65%
mentions🧪VCP-Mediated Autophagy Enhancement65%
mentions🧪Arginine Methylation Enhancement Therapy65%
mentions🧪Enteric Nervous System Prion-Like Propagation Blockade65%
mentions🧪Metabolic Circuit Breaker via Lipid Droplet Modulation65%
mentions🧪Extracellular Vesicle Biogenesis Modulation65%
mentions🧪Heat Shock Protein 70 Disaggregase Amplification65%
mentions🧪Autophagosome Maturation Checkpoint Control65%
mentions🧪PARP1 Inhibition Therapy65%
mentions🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation65%
mentions🧪Glycine-Rich Domain Competitive Inhibition65%
mentions🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna65%
mentions🧪Lysosomal Membrane Repair Enhancement65%
mentions🧪Flotillin-1 Stabilization Compounds65%
mentions🧪Nucleolar Stress Response Normalization65%
mentions🔬Quantitative proteomics of the aging synapse in early Alzhei60%
mentions🧫TRIM21-mediated K63-linked ubiquitination of G3BP160%
mentions🧫TRIM21 E3 ubiquitin ligase screen for stress granule regulat60%
mentions🧫Hyperoside-ACAT1 direct binding interaction studies60%
mentions🧫Computational Modeling of Alpha-Synuclein Propagation in PD60%
mentions🧫Autophagy Enhancement Drug Screening for Neurodegeneration60%
mentions🧫Prion Strain Diversity and Selective Vulnerability in CJD60%
mentions🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin60%
mentions🧫TDP-43 PET Ligand Development for FTD and ALS60%
see_also📖ACE Gene60%
see_also📖APEX2 Gene60%
see_also📖BAG260%
see_also📖CHMP1B — Charged Multivesicular Body Protein 1B60%
see_also📖EPHB2 Gene60%
see_also📖GLUL — Glutamine Synthetase60%
see_also📖kdm3a60%
see_also📖NUP98 — Nucleoporin 9860%
see_also📖PJA1 Gene — Praja1 RING Finger E3 Ubiquitin Ligase60%
see_also📖SPG20 Gene60%
see_also📖USP14 Gene60%
see_also📖XRCC6 Gene60%
see_also📖ZNF7 - Zinc Finger Protein 760%
see_also📖Aging vs Neurodegeneration: Mechanistic Comparison Matrix60%
see_also📖HERC2 Gene60%
see_also📖PINK1 — PTEN Induced Kinase 1 (PARK6)60%
see_also📖RNF2060%
see_also📖RNF5 — RING Finger Protein 560%
see_also📖YWHAB Gene60%
see_also📖Proteasome-Ubiquitin System Dysfunction Validation in Parkin60%
see_also📖UBR5 - Ubiquitin-Protein Ligase E3 Component N-Recognin 560%
see_also📖c9orf72-als-ftd-phenotype-mechanism60%
see_also📖Actin Cytoskeleton Dynamics in Neurodegeneration60%
see_also📖herc360%
see_also📖HERC6 — HECT and RLD Domain Containing E3 Ubiquitin Protein 60%
see_also📖APE1 — AP Endonuclease 160%
see_also📖DNAJC10 Gene60%
see_also📖SENP2 — SUMO Specific Peptidase 260%
see_also📖UBE2I — SUMO-Conjugating Enzyme60%
see_also📖ACTB Gene60%
see_also📖adam1060%
see_also📖JARID260%
see_also📖slc44a260%
see_also📖ABCD3 Gene60%
see_also📖DDX6 Gene60%
see_also📖FBXO45 - F-Box Protein 4560%
see_also📖PPP1R15B60%
see_also📖RPN2 Gene60%
see_also📖SUMO1 — Small Ubiquitin-Like Modifier 160%
see_also📖UBR4 — Ubiquitin Protein Ligase E3 Component N-Recognin 460%
see_also📖VPS13D Gene60%
see_also📖TRIM28 (KAP1) Protein60%
see_also📖UBE3A60%
see_also📖ABIN1 (TNIP1) Gene60%
see_also📖ACSL4 Gene - Acyl-CoA Synthetase Long Chain Family Member 460%
see_also📖DRAM1 Gene60%
see_also📖MARK2 Gene60%
see_also📖OTUD3 — OTU Deubiquitinase 360%
see_also📖PELI1 Gene60%
see_also📖PEX1 Gene - Peroxisome Biogenesis Factor 160%
see_also📖RAB11A — Ras-Related Protein Rab-11A60%
see_also📖RAB1A — Ras-Related Protein Rab-1A60%
see_also📖ACLY Inhibition Rescues Alpha-Synuclein Autophagy60%
see_also📖Protein Homeostasis in Neurodegeneration60%
see_also📖Protein Quality Control in Neurodegeneration60%
related🧪Mitochondrial-Lysosomal Contact Site Engineering58%
related🧪Circadian-Synchronized Proteostasis Enhancement58%
related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer58%
related🧪VCP-Mediated Autophagy Enhancement58%
related🧪Arginine Methylation Enhancement Therapy58%
related🧪Enteric Nervous System Prion-Like Propagation Blockade58%
related🧪Metabolic Circuit Breaker via Lipid Droplet Modulation58%
related🧪Extracellular Vesicle Biogenesis Modulation58%
related🧪Heat Shock Protein 70 Disaggregase Amplification58%
related🧪Autophagosome Maturation Checkpoint Control58%
related🧪PARP1 Inhibition Therapy58%
related🧪Microbial Metabolite-Mediated α-Synuclein Disaggregation58%
related🧪Glycine-Rich Domain Competitive Inhibition58%
related🧪Hippocampal CA3-CA1 circuit rescue via neurogenesis and syna58%
related🧪Lysosomal Membrane Repair Enhancement58%
related🧪Flotillin-1 Stabilization Compounds58%
related🧪Nucleolar Stress Response Normalization58%
related🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro55%
related🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th55%
related🔬Quantitative proteomics of the aging synapse in early Alzhei54%
related🧫TRIM21-mediated K63-linked ubiquitination of G3BP154%
related🧫TRIM21 E3 ubiquitin ligase screen for stress granule regulat54%
related🧫Hyperoside-ACAT1 direct binding interaction studies54%
related🧫Computational Modeling of Alpha-Synuclein Propagation in PD54%
related🧫Autophagy Enhancement Drug Screening for Neurodegeneration54%
related🧫Prion Strain Diversity and Selective Vulnerability in CJD54%
related🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin54%
related🧫TDP-43 PET Ligand Development for FTD and ALS54%
mentions🧪Selective HDAC3 Inhibition with Cognitive Enhancement50%
mentions🧪HSP90-Tau Disaggregation Complex Enhancement50%
mentions🧪SASP-Mediated Cholinergic Synapse Disruption50%
mentions🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition50%
mentions🧪Senescent Microglia Resolution via Maresins-Senolytics Combi50%
mentions🧪Nutrient-Sensing Epigenetic Circuit Reactivation50%
mentions🧪Cryptic Exon Silencing Restoration50%
mentions🧪SIRT6-NAD+ Axis Enhancement Therapy50%
mentions🧪GAP43-mediated tunneling nanotube stabilization enhances neu50%
mentions🧪DNMT1-Targeting Antisense Oligonucleotide Reset50%
mentions🧪Prohibitin-2 Mitochondrial Cross-Seeding Hub Disruption50%
mentions🧪Astrocyte-Mediated Neuronal Epigenetic Rescue50%
mentions🧪Stress Granule Phase Separation Modulators50%
mentions🧪HDAC3-Selective Inhibition for Clock Reset50%
mentions🧪Chromatin Accessibility Restoration via BRD4 Modulation50%
mentions🧪Transcriptional Autophagy-Lysosome Coupling50%
mentions🧪Digital Twin-Guided Metabolic Reprogramming50%
mentions🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides50%
mentions🧪Gamma entrainment therapy to restore hippocampal-cortical sy50%
mentions🧪R-Loop Resolution Enhancement Therapy50%
mentions🧪Competitive APOE4 Domain Stabilization Peptides50%
mentions🧪Epigenetic Memory Erasure via TET2 Activation50%
mentions🧪HCN1-Mediated Resonance Frequency Stabilization Therapy50%
mentions🧪TFEB-PGC1α Mitochondrial-Lysosomal Decoupling50%
mentions🧪Microbial Inflammasome Priming Prevention50%
mentions🧪Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution50%
mentions🧪Near-infrared light therapy stimulates COX4-dependent mitoch50%
mentions🧪FOXO3-Longevity Pathway Epigenetic Reprogramming50%
mentions🧪RNA Granule Nucleation Site Modulation50%
mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%
mentions🧫Proteasome-Ubiquitin System Dysfunction Validation in Parkin50%
mentions🧪Mitochondrial-Lysosomal Contact Site Engineering50%
mentions🧪Circadian-Synchronized Proteostasis Enhancement50%
mentions🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer50%
mentions🧪PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor50%
mentions🧪Nucleolar Stress Response Normalization50%
mentions🧪SIRT3-Mediated Mitochondrial Deacetylation Failure with PINK50%
mentions🧪ACSL4-Driven Ferroptotic Priming in Disease-Associated Micro50%
mentions🧪Astrocytic Lipoxin A4 Pathway Restoration via ALOX15 Gene Th50%
mentions🧪APOE4 Allosteric Rescue via Small Molecule Chaperones50%
mentions🧪Interfacial Lipid Mimetics to Disrupt Domain Interaction50%
mentions🧪Targeted APOE4-to-APOE3 Base Editing Therapy50%
mentions🧪APOE Isoform Expression Across Glial Subtypes50%
mentions🧪Circadian Rhythm Entrainment of Reactive Astrocytes50%
mentions🧪Temporal Decoupling via Circadian Clock Reset50%
mentions🧪Circadian Clock-Autophagy Synchronization50%
mentions🧪Phase-Separated Organelle Targeting50%
mentions🧪GFAP-Positive Reactive Astrocyte Subtype Delineation50%
mentions🧪CX43 hemichannel engineering enables size-selective mitochon50%
mentions🧪Astroglial Gap Junction Coordination via Connexin-43 Phospho50%
mentions🧪Lysosomal Positioning Dynamics Modulation50%
mentions🧪LRP1-Dependent Tau Uptake Disruption50%
mentions🧪Mitochondrial Transfer Pathway Enhancement50%
mentions🧪Extracellular Matrix Stiffness Modulation50%
mentions🧪RAB27A-dependent extracellular vesicle engineering for mitoc50%
mentions🧪Mitochondrial-Nuclear Epigenetic Cross-Talk Restoration50%
mentions🧪Cross-Seeding Prevention Strategy50%
mentions🧪TFAM overexpression creates mitochondrial donor-recipient gr50%
mentions🧪TREM2 Conformational Stabilizers for Synaptic Discrimination50%
mentions🧪TREM2-mediated microglial tau clearance enhancement50%
mentions🧪Cell-Type Specific TREM2 Upregulation in DAM Microglia50%
mentions🧪Quantum Coherence Disruption in Cellular Communication50%
mentions🧪APOE-Dependent Autophagy Restoration50%
mentions🧪PINK1/Parkin-Independent Mitophagy Bypass for Enhanced Donor50%
mentions🧪RNA-Binding Competition Therapy for TDP-43 Cross-Seeding50%
mentions🧪HSP70 Co-chaperone DNAJB6 Universal Cross-Seeding Inhibitor50%
mentions🧪The Mitochondrial-Lysosomal Metabolic Coupling Dysfunction50%
mentions🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m50%
related🔬What are the mechanisms underlying selective vulnerability o50%
related🔬What are the mechanisms underlying astrocyte reactivity subt50%
related🔬What are the mechanisms underlying blood-brain barrier trans50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬What are the mechanisms underlying selective vulnerability o50%
related🔬What are the mechanisms underlying tdp-43 phase separation t50%
related🔬What are the mechanisms underlying astrocyte reactivity subt50%
related🔬What are the mechanisms underlying blood-brain barrier trans50%
related🔬What are the mechanisms underlying microglia-astrocyte cross50%
related🔬What are the mechanisms underlying apoe4 structural biology 50%
related🔬What are the mechanisms underlying autophagy-lysosome pathwa50%
related🔬What are the mechanisms underlying digital biomarkers and ai50%
related🔬What are the mechanisms underlying senolytic therapy for age50%
related🔬What are the mechanisms underlying neuroinflammation resolut50%
related🔬What are the mechanisms underlying what are the mechanisms b50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying protein aggregation cross50%
related🔬Investigate how lipid raft composition (cholesterol metaboli50%
related🔬What are the mechanisms underlying rna binding protein dysre50%
related🔬What are the mechanisms underlying synaptic pruning by micro50%
related🔬What are the mechanisms underlying mitochondrial transfer be50%
related🔬What are the mechanisms underlying epigenetic clocks and bio50%
related🔬Analyze circuit-level changes in neurodegeneration using All50%
related🔬What gene expression changes in the aging mouse brain predic50%
related🔬Epigenetic reprogramming in aging neurons50%
related🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc50%
related🔬Investigate prion-like spreading of tau pathology through co50%
related🔬How does metabolic reprogramming (glucose metabolism shifts,50%
mentions📖Aarhus University40%
mentions📖Angelman Syndrome Foundation40%
mentions📖Baylor College of Medicine40%
mentions📖Cyclica Inc40%
mentions📖Cyclica40%
mentions📖Gladstone Institutes40%
mentions📖Icahn School of Medicine at Mount Sinai40%
mentions📖John Ravits40%
mentions📖Johns Hopkins University40%
mentions📖KeifeRx40%
mentions📖Kinevo Inc.40%
mentions📖Kyoto University40%
mentions📖MitoRestore Pharmaceuticals40%
mentions📖Mochida Pharmaceutical Co., Ltd.40%
mentions📖Osaka University40%
mentions📖Peking University40%
mentions📖Peking University40%
mentions📖Prionab40%
mentions📖Ronald C. Petersen40%
mentions📖Taiping Zhang40%
mentions📖Toyo Biotechnology40%
mentions📖Universitat de Barcelona40%
mentions📖University of Barcelona40%
mentions📖University of California Santa Barbara40%
mentions📖University of Cambridge - MRC LMB40%
mentions📖University of Miami40%
mentions📖University of Nottingham40%
mentions📖University of Pennsylvania40%
mentions📖University of Rostock40%
mentions📖University of Tokyo40%
mentions📖indiana-university-school-of-medicine40%
mentions📖scineuro-pharmaceuticals40%
mentions📖university-of-basel40%
mentions📖university-of-virginia40%
mentions📖uthealth-houston40%
mentions🔬Analyze circuit-level changes in neurodegeneration using All40%
related🧪Selective HDAC3 Inhibition with Cognitive Enhancement40%
related🧪HSP90-Tau Disaggregation Complex Enhancement40%
related🧪SASP-Mediated Cholinergic Synapse Disruption40%
related🧪Designer TRAK1-KIF5 fusion proteins accelerate therapeutic m40%
related🧪Metabolic Reprogramming via Microglial Glycolysis Inhibition40%
related🧪Senescent Microglia Resolution via Maresins-Senolytics Combi40%
related🧪Nutrient-Sensing Epigenetic Circuit Reactivation40%
related🧪Cryptic Exon Silencing Restoration40%
related🧪SIRT6-NAD+ Axis Enhancement Therapy40%
related🧪GAP43-mediated tunneling nanotube stabilization enhances neu40%
related🧪DNMT1-Targeting Antisense Oligonucleotide Reset40%
related🧪Stress Granule Phase Separation Modulators40%
related🧪HDAC3-Selective Inhibition for Clock Reset40%
related🧪Chromatin Accessibility Restoration via BRD4 Modulation40%
related🧪Transcriptional Autophagy-Lysosome Coupling40%
related🧪Digital Twin-Guided Metabolic Reprogramming40%
related🧪Engineered Apolipoprotein E4-Neutralizing Shuttle Peptides40%
related🧪Gamma entrainment therapy to restore hippocampal-cortical sy40%
related🧪R-Loop Resolution Enhancement Therapy40%
related🧪Competitive APOE4 Domain Stabilization Peptides40%
related🧪Epigenetic Memory Erasure via TET2 Activation40%
related🧪HCN1-Mediated Resonance Frequency Stabilization Therapy40%
related🧪Microbial Inflammasome Priming Prevention40%
related🧪Oligodendrocyte Protectin D1 Mimetic for Myelin Resolution40%
related🧪Near-infrared light therapy stimulates COX4-dependent mitoch40%
related🧪FOXO3-Longevity Pathway Epigenetic Reprogramming40%
related🧪RNA Granule Nucleation Site Modulation40%
related🔬What are the mechanisms underlying tdp-43 phase separation t39%
mentions🔬What are the mechanisms underlying selective vulnerability o35%
mentions🔬What are the mechanisms underlying tdp-43 phase separation t35%
mentions🔬What are the mechanisms underlying astrocyte reactivity subt35%
mentions🔬What are the mechanisms underlying blood-brain barrier trans35%
mentions🔬What are the mechanisms underlying microglia-astrocyte cross35%
mentions🔬What are the mechanisms underlying apoe4 structural biology 35%
mentions🔬What are the mechanisms underlying autophagy-lysosome pathwa35%
mentions🔬What are the mechanisms underlying digital biomarkers and ai35%
mentions🔬What are the mechanisms underlying senolytic therapy for age35%
mentions🔬What are the mechanisms underlying neuroinflammation resolut35%
mentions🔬What are the mechanisms underlying what are the mechanisms b35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬What are the mechanisms underlying protein aggregation cross35%
mentions🔬Investigate how lipid raft composition (cholesterol metaboli35%
mentions🔬What are the mechanisms underlying rna binding protein dysre35%
mentions🔬What are the mechanisms underlying synaptic pruning by micro35%
mentions🔬What are the mechanisms underlying mitochondrial transfer be35%
mentions🔬What are the mechanisms underlying epigenetic clocks and bio35%
mentions🔬What gene expression changes in the aging mouse brain predic35%
mentions🔬Epigenetic reprogramming in aging neurons35%
mentions🔬Cell type vulnerability in Alzheimers Disease (SEA-AD transc35%
mentions🔬Investigate prion-like spreading of tau pathology through co35%
mentions🔬How does metabolic reprogramming (glucose metabolism shifts,35%
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