Real-time closed-loop transcranial focused ultrasound targeting PV interneurons with API-integrated biomarker validation in Alzheimer's disease

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This hypothesis proposes using closed-loop transcranial focused ultrasound (tFUS) to restore hippocampal gamma oscillations in Alzheimer's disease through direct acoustic mechanostimulation of parvalbumin-positive (PV) interneurons, with real-time validation through API-integrated biomarker systems. The approach leverages the unique mechanosensitive properties of PV interneurons' high-density volt