Real-time closed-loop transcranial focused ultrasound targeting PVALB interneurons with continuous gamma oscillation feedback monitoring for precision neuromodulation in Alzheimer's disease

h-var-1a318725cd

This hypothesis proposes a precision neuromodulation system that combines transcranial focused ultrasound (tFUS) targeting of CA1 parvalbumin-positive (PV) interneurons with real-time electroencephalography feedback to restore gamma oscillations in Alzheimer's disease. The system employs a closed-loop architecture where continuous monitoring of hippocampal gamma power (30-100 Hz) through high-dens