Closed-loop transcranial focused ultrasound with real-time gamma feedback to restore PV interneuron function in Alzheimer's disease

h-var-521f97f447

Alzheimer's disease pathogenesis involves early dysfunction of parvalbumin-positive (PV) interneurons in hippocampal CA1, leading to collapsed gamma oscillations (30-100 Hz) that are essential for memory encoding. PV interneurons, expressing the PVALB gene, provide perisomatic inhibition to pyramidal cells and generate the precise timing necessary for gamma rhythms. Amyloid-beta oligomers preferen