Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via SST interneuron disinhibition cascades in Alzheimer's disease

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This intervention targets somatostatin-positive (SST) interneurons in the stratum oriens to restore hippocampal gamma oscillations through disinhibition of parvalbumin-positive (PV) interneurons in Alzheimer's disease. While amyloid-beta oligomers directly impair PV interneuron function, SST interneurons in the hippocampal CA1 region provide a critical regulatory layer by forming inhibitory synaps