Closed-loop transcranial focused ultrasound with gamma entrainment to restore hippocampal-cortical synchrony via PV interneuron mechanostimulation

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This hypothesis combines the precision of transcranial focused ultrasound (tFUS) targeting with gamma entrainment therapy to restore hippocampal-cortical synchrony in Alzheimer's disease. The intervention uses closed-loop tFUS specifically targeted to CA1 parvalbumin-positive (PV) interneurons, guided by real-time monitoring of gamma oscillations, while simultaneously delivering 40 Hz acoustic ent