Closed-loop transcranial focused ultrasound to restore hippocampal gamma oscillations via glymphatic-mediated amyloid clearance and secondary PV interneuron disinhibition in Alzheimer's disease

h-var-dce97ca507

**Background and Rationale** Alzheimer's disease (AD) manifests early hippocampal network dysfunction characterized by progressive loss of gamma oscillations critical for memory encoding. While gamma rhythms depend on parvalbumin-positive (PV) interneuron function, emerging evidence indicates that amyloid-beta accumulation directly impairs PV interneurons through toxic oligomer binding and metabo