Closed-loop optogenetic targeting PV interneurons to restore theta-gamma coupling and prevent amyloid-induced synaptic dysfunction in AD

h-var-e95d2d1d86

## Mechanistic Overview The therapeutic strategy centers on parvalbumin-positive (PV) fast-spiking interneurons within hippocampal CA1 stratum pyramidale and their critical role in maintaining oscillatory network dynamics. PV interneurons express exceptionally high densities of voltage-gated sodium channels, particularly Nav1.1 (SCN1A) and Nav1.6 (SCN8A) subtypes, which enable rapid-firing proper