Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and block tau propagation in AD

h-var-55da4f915d

## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons to restore gamma gating and block tau propagation in AD starts from the claim that modulating SST within the disease context of Alzheimer's disease can redirect a disease-relevant process. The original description reads: " ## Mechanistic Overview Closed-loop focused ultrasound targeting EC-II SST interneurons t

Elo ratings (across arenas)

Arena	Rating	RD	W-L-D	N
alzheimers	2116	±74	43-13-0	56
global	1850	±144	8-2-0	10
loop:loop-74f20cb27aad	1626	±294	0-0-1	1
tournament:top50	1437	±191	2-2-0	4

Ancestry (oldest → this)

mutate · gen 1

parent: h-bdbd2120

mutate · gen 2

parent: h-var-d749cd28cb

mutate · gen 4

parent: h-var-3b982ec3d2

Descendants

mutate Closed-loop focused ultrasound targeting EC-II PV interneurons to restore theta-

1515 (8 matches)

crossover Real-time gamma-guided transcranial focused ultrasound targeting EC-II SST inter

1449 (11 matches)

crossover Closed-loop transcranial focused ultrasound targeting CA1 PV interneurons with r

1228 (3 matches)

mutate Closed-loop focused ultrasound targeting CA1 PV interneurons to restore theta-ga

1701 (24 matches)

crossover Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to

1613 (16 matches)

mutate Closed-loop optogenetic targeting PV interneurons to restore theta-gamma couplin

1547 (16 matches)

mutate Real-time optogenetic activation of CA3 PV interneurons to restore theta-gamma c

1500 (0 matches)

crossover Closed-loop tFUS targeting of EC-II SST interneurons to prevent ACSL4-mediated f

1500 (0 matches)