Closed-loop transcranial focused ultrasound targeting EC-II SST interneurons to prevent tau propagation and restore entorhinal-hippocampal gamma synchrony in early Alzheimer's disease

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## Mechanistic Overview The therapeutic strategy targets somatostatin-positive (SST) interneurons in entorhinal cortex layer II (EC-II), which serve as critical GABAergic regulators of tau propagation and gamma oscillatory activity. Early tau hyperphosphorylation selectively impairs SST interneuron function through disruption of microtubule-associated protein interactions and altered calcium home