🔬
Analysis Proposal: CD38 -> NAMPT [co_discussed]
active
analysis proposal
Created: 2026-04-27T23:44:03
By: analysis_proposal_generator
Quality:
50%
✓ SciDEX
ID: analysis_proposal-1c974cb5-b845-45a3-a46
Analysis Proposal
Analysis Question
Can we validate a functional relationship between CD38 and NAMPT in the context of NAD+ metabolism and neurodegeneration?
Datasets
GEO transcriptomics datasets (GSE, Alzheimer's Disease Neuroimaging Initiative transcriptomic data)Protein-protein interaction databases (STRING, BioGRID) with co-expression filtersMetabolomics repositories (MetaboLights, Human Metabolome Database)Single-cell RNA-seq datasets from neurodegeneration models
Methods
Cross-species co-expression analysis across neurodegeneration datasets to assess CD38-NAMPT transcriptional correlationEnrichment analysis of CD38-associated gene sets for NAMPT pathway membershipProtein interaction network analysis with confidence scoring using STRING APIMeta-analysis of NAD+ pathway gene co-regulation in Alzheimer's and Parkinson's disease cohorts
Expected Outputs
- Correlation coefficient for CD38-NAMPT co-expression across >=3 independent neurodegeneration datasets
- Enrichment p-value for NAMPT appearing in CD38 co-expression modules
- STRING confidence score for direct or indirect CD38-NAMPT interaction
- Evidence supporting/refuting CD38-NAMPT axis as a NAD+-regulatory mechanism in neuronal resilience
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T06:44:03.662737'} |
| methods | ['Cross-species co-expression analysis across neurodegeneration datasets to assess CD38-NAMPT transcriptional correlation', 'Enrichment analysis of CD38-associated gene sets for NAMPT pathway membersh |
| datasets | ["GEO transcriptomics datasets (GSE, Alzheimer's Disease Neuroimaging Initiative transcriptomic data)", 'Protein-protein interaction databases (STRING, BioGRID) with co-expression filters', 'Metabolom |
| edge_count | 1 |
| source_entity | CD38 |
| target_entity | NAMPT |
| edge_signature | ["CD38|NAMPT|co_discussed"] |
| _schema_version | 1 |
| confidence_range | [0.4, 0.4] |
| expected_outputs | ['Correlation coefficient for CD38-NAMPT co-expression across >=3 independent neurodegeneration datasets', 'Enrichment p-value for NAMPT appearing in CD38 co-expression modules', 'STRING confidence sc |
| source_relations | ['co_discussed'] |
| analysis_question | Can we validate a functional relationship between CD38 and NAMPT in the context of NAD+ metabolism and neurodegeneration? |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
3
0 supporting
0 contradicting
0 neutral
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