🔬
Analysis Proposal: PLA2G6 -> PLA2G4A [co_discussed, interacts_with]
active
analysis proposal
Created: 2026-04-28T00:03:25
By: analysis_proposal_generator
Quality:
50%
✓ SciDEX
ID: analysis_proposal-2d7148a5-688f-43dd-8b0
Analysis Proposal
Analysis Question
Can we validate the co-discussion and protein interaction relationships between PLA2G6 and PLA2G4A in neurodegeneration contexts?
Datasets
GTEx v8 gene expression data (brain tissue)AlzData neurodegeneration multi-omics databaseSTRING v12 protein-protein interaction databaseGWAS Catalog (neuroscience-related phenotype summary statistics)
Methods
Pearson/Spearman co-expression analysis across brain region RNA-seq cohortsBayesian network inference for shared regulatory pathwaysFunctional enrichment overlap analysis (GO, KEGG, Reactome)LDSC-based colocalization to assess shared genetic architecture
Expected Outputs
- Co-expression correlation coefficients with 95% CI and Benjamini-Hochberg adjusted p-values
- Mutual information scores and directionality indicators for regulatory relationships
- Enrichment odds ratios and FDR values for shared neuroinflammatory/oxidative stress pathways
- Colocalization posterior probabilities (PP4) indicating shared causal variants
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T07:03:25.517389'} |
| methods | ['Pearson/Spearman co-expression analysis across brain region RNA-seq cohorts', 'Bayesian network inference for shared regulatory pathways', 'Functional enrichment overlap analysis (GO, KEGG, Reactome |
| datasets | ['GTEx v8 gene expression data (brain tissue)', 'AlzData neurodegeneration multi-omics database', 'STRING v12 protein-protein interaction database', 'GWAS Catalog (neuroscience-related phenotype summa |
| edge_count | 2 |
| source_entity | PLA2G6 |
| target_entity | PLA2G4A |
| edge_signature | ["PLA2G6|PLA2G4A|co_discussed", "PLA2G6|PLA2G4A|interacts_with"] |
| _schema_version | 1 |
| confidence_range | [0.4, 0.482] |
| expected_outputs | ['Co-expression correlation coefficients with 95% CI and Benjamini-Hochberg adjusted p-values', 'Mutual information scores and directionality indicators for regulatory relationships', 'Enrichment odds |
| source_relations | ['co_discussed', 'interacts_with'] |
| analysis_question | Can we validate the co-discussion and protein interaction relationships between PLA2G6 and PLA2G4A in neurodegeneration contexts? |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
3
0 supporting
0 contradicting
0 neutral
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