gene

PLA2G4A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLA2G4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

142Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

PLA2G4A is a gene implicated in neurodegeneration research. Key relationships include: co discussed, inhibits, associated with. Associated with ALS, Als, Ms. Connected to 45 entities in the SciDEX knowledge graph.

View on Wiki →

🧬 Gene Info

Gene Symbol	PLA2G4A
Protein Type	Enzyme
Target Class	Enzyme
Function	Small molecule inhibitor of cytosolic phospholipase A2 enzymatic activity
Mechanism of Action	Small molecule inhibitor of cytosolic phospholipase A2 enzymatic activity
Druggability	Low (0.40)
Clinical Stage	Phase II
Pathways	Cellular senescence / SASP signaling, Prostaglandin Biosynthesis
UniProt ID	P47712
GeneCards	PLA2G4A
Human Protein Atlas	PLA2G4A
Associated Diseases	ALS, Ms, erotomanic delusion, neurodegeneration, poverty of thought
Known Drugs/Compounds	PYR-1
Interactions	PLA2G6, TAU, Rb, RBFOX3, AUTOPHAGY, PLA2G3
SciDEX Target	View Target Profile (5 clinical trials)
KG Connections	142 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PLA2G4A — AlphaFold P47712 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (17)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PLA2G4A["PLA2G4A"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PLA2G4A["PLA2G4A"] -->|"interacts"| PLA2G6["PLA2G6"]
    PLA2G6_1["PLA2G6"] -->|"interacts"| PLA2G4A["PLA2G4A"]
    MMP9["MMP9"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    SLC7A11["SLC7A11"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    AQP4["AQP4"] -->|"co discussed"| PLA2G4A["PLA2G4A"]
    style PLA2G4A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (86)

Target	Relation	Type	Str
cytosolic phospholipase A2	associated_with	protein	0.95
Schizophrenia	risk_factor_for	disease	0.95
Cytosolic PLA2	regulates	protein	0.92
Copy Number Deletion	associated_with	mechanism	0.90
Cytosolic Phospholipase A2	regulates	protein	0.90
Cytosolic Phospholipase A2	downregulates	protein	0.90
Cpla2	regulates	protein	0.90
Poverty Of Thought	correlates_with	phenotype	0.85
Erotomanic Delusion	correlates_with	phenotype	0.85
Cytosolic Phospholipase A2	biomarker_for	biomarker	0.85
schizophrenia	affects	disease	0.80
poverty of thought	associated_with	phenotype	0.75
erotomanic delusion	associated_with	phenotype	0.75
Ms	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
ALS	associated_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	causes	disease	0.65
PLA2G6	upregulates	entity	0.60
PLA2G6	regulates	entity	0.60
PLA2G6	expressed_in	entity	0.60
PLA2G6	associated_with	entity	0.60
TAU	expressed_in	entity	0.60
SCHIZOPHRENIA	associated_with	entity	0.60
SCHIZOPHRENIA	upregulates	entity	0.60
SCHIZOPHRENIA	expressed_in	entity	0.60
PLA2G6	activates	gene	0.60
PLA2G6	inhibits	gene	0.60
TAU	inhibits	gene	0.60
neurodegeneration	implicated_in	disease	0.60
Rb	inhibits	protein	0.60
schizophrenia	associated_with	disease	0.60
schizophrenia	biomarker_for	disease	0.60
schizophrenia	expressed_in	disease	0.60
PLA2G6	treats	gene	0.60
schizophrenia	interacts_with	disease	0.60
PLA2G6	binds_to	gene	0.60
schizophrenia	modulates	disease	0.60
neurodegeneration	activates	disease	0.60
RBFOX3	activates	gene	0.60
GENES	expressed_in	gene	0.60
Autophagy	inhibits	pathway	0.60
AUTOPHAGY	inhibits	gene	0.60
AND	associated_with	gene	0.60
PLA2G3	activates	gene	0.60
AND	expressed_in	gene	0.60
T Cell	activates	cell_type	0.60
PLA2G12F	activates	gene	0.60

Incoming (56)

Source	Relation	Type	Str
Copy number deletion	downregulates	process	0.90
PYR-1	inhibits	drug	0.90
h-bb518928	targets_gene	hypothesis	0.90
PDBu	upregulates	drug	0.85
IFNT	downregulates	protein	0.85
h-bb518928	targets	hypothesis	0.80
PLA2G6	activates	gene	0.60
PLA2G6	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ACTB	activates	gene	0.60
ATG12	activates	gene	0.60
ATG5	activates	gene	0.60
ATG7	activates	gene	0.60
BECN1	activates	gene	0.60
CTSD	activates	gene	0.60
CTSL	activates	gene	0.60
LAMP1	activates	gene	0.60
LAMP2	activates	gene	0.60
LC3	activates	gene	0.60
NAGLU	activates	gene	0.60
GENES	expressed_in	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
AND	inhibits	gene	0.60
PLA2G12F	activates	gene	0.60
PLA2G3	activates	gene	0.60
PLA2G4F	activates	gene	0.60
AND	expressed_in	gene	0.60
PLA2G12F	interacts_with	gene	0.60
PLA2G3	interacts_with	gene	0.60
GFP	activates	gene	0.60
MAP1LC3	activates	gene	0.60
ERK1	activates	gene	0.55
MBP	expressed_in	gene	0.55
PLA2G6	regulates	gene	0.50
PLA2G6	expressed_in	gene	0.50
PLA2G6	associated_with	gene	0.50
SCHIZOPHRENIA	associated_with	disease	0.50
SCHIZOPHRENIA	activates	disease	0.50
SCHIZOPHRENIA	inhibits	disease	0.50
PLA2G6	interacts_with	gene	0.48
MMP9	co_discussed	gene	0.40
SLC7A11	co_discussed	gene	0.40
AQP4	co_discussed	gene	0.40
CD38	co_discussed	gene	0.40
C1Q	co_discussed	gene	0.40
NAMPT	co_discussed	gene	0.40
GPX4	co_discussed	gene	0.40
PLA2G6	co_discussed	gene	0.40
MMP2	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PLA2G4A

Understanding Entity Pages

Summary

Wiki Pages (17)

Cellular Senescence in Neurodegeneration

Section 191: Advanced Lipid Signaling Modulators in CBS/PSP

PLA2G6 Protein

Deep Brain Stimulation

Schizophrenia

L23 Interneurons Schizophrenia

NAGLU — Alpha-N-Acetylglucosaminidase

Age-Sensitive Cortical Vulnerability in Parkinson's Disease

CD38 Molecule (CD38)

PLA2G6 — Phospholipase A2 Group VI

Parvalbumin Interneurons in Schizophrenia

REL Gene

NF-κB p65 Protein

RELA (NF-κB p65)

PLA2G6 Protein (iPLA2-VI)

VTA Dopamine Neurons in Schizophrenia