gene

PLA2G6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLA2G6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

215Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

PLA2G6 is a gene implicated in neurodegeneration research. Key relationships include: associated with, co discussed, activates. Associated with ALS, Aging, Als. Connected to 63 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLA2G6
Full Name	Phospholipase A2 Group VI
Aliases	iPLA2-VI
Chromosome	22q13.1
Protein Type	Enzyme
Target Class	Enzyme
Function	Phospholipid remodeling - generates lysophospholipids and free fatty acids
Mechanism of Action	Small molecule inhibitor of calcium-independent phospholipase A2 activity
Druggability	Low (0.36)
Clinical Stage	Approved
Molecular Weight	90 kDa
Amino Acids	752 aa
Pathways	Cellular senescence / SASP signaling, Ros
UniProt ID	Q9NP81
GeneCards	PLA2G6
Human Protein Atlas	PLA2G6
Associated Diseases	ALS, ALZHEIMER, Dystonia, Ms
Known Drugs/Compounds	BEL
Interactions	PLA2G4A, TAU, HDAC3, MECP2, Rb, WDR45
SciDEX Target	View Target Profile (8 clinical trials)
KG Connections	215 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PLA2G6 — AlphaFold Q9NP81 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PLA2G6["PLA2G6"] -->|"associated"| neurodegeneration["neurodegeneration"]
    PLA2G6["PLA2G6"] -->|"interacts"| PLA2G4A["PLA2G4A"]
    PLA2G6["PLA2G6"] -->|"co discussed"| MMP2["MMP2"]
    PLA2G6["PLA2G6"] -->|"co discussed"| C3["C3"]
    PLA2G6["PLA2G6"] -->|"co discussed"| PLA2G4A_1["PLA2G4A"]
    PLA2G6["PLA2G6"] -->|"co discussed"| IL1B["IL1B"]
    PLA2G4A_2["PLA2G4A"] -->|"interacts"| PLA2G6["PLA2G6"]
    MMP9["MMP9"] -->|"co discussed"| PLA2G6["PLA2G6"]
    SLC7A11["SLC7A11"] -->|"co discussed"| PLA2G6["PLA2G6"]
    AQP4["AQP4"] -->|"co discussed"| PLA2G6["PLA2G6"]
    style PLA2G6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (130)

Target	Relation	Type	Str
Phospholipase A2 Group VI-Associated Neurodegeneration	causes	disease	0.95
arachidonic acid	associated_with	compound	0.90
demyelination	associated_with	biological_process	0.80
neurodegeneration	causes	disease	0.80
neurodegeneration	interacts_with	disease	0.80
myelin lipids	modifies	structure	0.80
Schizophrenia	risk_factor_for	disease	0.78
Neurodegeneration	associated_with	disease	0.75
VPS13C	associated_with	gene	0.70
GENES	associated_with	gene	0.70
Parkinson's disease	causes	disease	0.70
Parkinson's disease	interacts_with	disease	0.70
Ms	associated_with	disease	0.65
Schizophrenia	activates	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Als	activates	disease	0.65
Parkinson	associated_with	disease	0.65
Dystonia	associated_with	disease	0.65
Ms	inhibits	disease	0.65
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Parkinson	activates	disease	0.65
ALS	associated_with	disease	0.65
Ischemia	activates	disease	0.65
Stroke	activates	disease	0.65
ALS	activates	disease	0.65
Alzheimer	associated_with	disease	0.65
PLA2G4A	activates	gene	0.60
PLA2G4A	inhibits	gene	0.60
PANK2	associated_with	gene	0.60
MAX	therapeutic_target	gene	0.60
BID	therapeutic_target	gene	0.60
TAU	inhibits	gene	0.60
neurodegeneration	implicated_in	disease	0.60
HDAC3	activates	gene	0.60
MECP2	inhibits	gene	0.60
PRKN	associated_with	gene	0.60
ATP1A3	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
Rb	inhibits	protein	0.60
schizophrenia	associated_with	disease	0.60
schizophrenia	interacts_with	disease	0.60
axon	associated_with	organelle	0.60
neurodegeneration	biomarker_for	disease	0.60
neurodegeneration	disrupts	disease	0.60
RAB39B	associated_with	gene	0.60
WDR45	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60

Incoming (85)

Source	Relation	Type	Str
h-bb518928	targets_gene	hypothesis	0.90
BEL	inhibits	drug	0.85
h-bb518928	targets	hypothesis	0.80
oxidized phosphatidylcholines	causes	chemical	0.80
PANK2	associated_with	gene	0.70
TREM2	upregulates	gene	0.70
FTL	associated_with	gene	0.60
WDR45	associated_with	gene	0.60
COASY	associated_with	gene	0.60
DCAF17	associated_with	gene	0.60
FA2H	associated_with	gene	0.60
C19ORF12	associated_with	gene	0.60
PLA2G4A	activates	gene	0.60
PLA2G4A	inhibits	gene	0.60
PLA2G4A	upregulates	entity	0.60
PLA2G4A	regulates	entity	0.60
PLA2G4A	expressed_in	entity	0.60
PLA2G4A	associated_with	entity	0.60
MECP2	associated_with	entity	0.60
HDAC3	activates	gene	0.60
MECP2	inhibits	gene	0.60
GCH1	associated_with	gene	0.60
VPS35	associated_with	gene	0.60
GBA1	associated_with	gene	0.60
TARDBP	associated_with	gene	0.60
PARK7	associated_with	gene	0.60
DNAJC13	associated_with	gene	0.60
FBXO7	associated_with	gene	0.60
PINK1	associated_with	gene	0.60
VPS13C	associated_with	gene	0.60
DNAJC6	associated_with	gene	0.60
ATP13A2	associated_with	gene	0.60
PLA2G4A	treats	gene	0.60
PLA2G4A	binds_to	gene	0.60
GBA	associated_with	gene	0.60
LRRK2	associated_with	gene	0.60
ATXN2	associated_with	gene	0.60
PANK2	interacts_with	gene	0.60
ATP13A2	interacts_with	gene	0.60
DNAJC6	interacts_with	gene	0.60
FBXO7	interacts_with	gene	0.60
PINK1	interacts_with	gene	0.60
ATP1A3	associated_with	gene	0.60
CP	interacts_with	gene	0.60
DCAF17	interacts_with	gene	0.60
FA2H	interacts_with	gene	0.60
FTL	interacts_with	gene	0.60
GENES	associated_with	gene	0.60
PLA2G3	activates	gene	0.60
AND	expressed_in	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

neurodegeneration | 2026-04-15 | 0 hypotheses

Senolytic therapy for age-related neurodegeneration

neurodegeneration | 2026-04-01 | 8 hypotheses Top: 0.703

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PLA2G6

Understanding Entity Pages

Summary

Wiki Pages (21)

PLA2G6 — Phospholipase A2 Group VI

Progressive Supranuclear Palsy (PSP)

Multiple System Atrophy

Alzheimer's Disease

deferiprone-neurodegeneration

Cellular Senescence in Neurodegeneration

Infantile Neuroaxonal Dystrophy (INAD)

Neuroferritinopathy

Diseases

PKAN Mechanistic Pathway

SLC6A3 Gene

FRRS1 — Ferric Chelate Reductase 1

Axonal Spheroids in Neurodegeneration

C19orf12 Gene - Chromosome 19 Open Reading Frame 12

Iron Dysregulation in Neurodegeneration

Section 191: Advanced Lipid Signaling Modulators in CBS/PSP

Pantothenate Kinase-Associated Neurodegeneration (PKAN)

metal-dyshomeostasis

Globus Pallidus

PLA2G6 Protein

Globus Pallidus Pkan