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Neuroimmune modulation and Aβ clearance mechanisms

experiment Created: 2026-04-10 22:46:49 By: experiment_extractor Quality: 82% ✓ SciDEX ID: experiment-exp-09e8c128-8a21-4e7f-bc75-3
🧫 Experiment Protocol Cell Biology
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Related Entities
HDAC4, NHE6, LAMP2
Metadata
experiment_typecell_biology
protocolAssessment of phagocytic receptor expression, microglial recruitment assays, measurement of LAMP2 expression, evaluation of autophagy-lysosomal function in astrocytes
expected_outcomesUpregulated phagocytic receptors, increased microglial Aβ phagocytosis, enhanced astrocytic autophagy-lysosomal function
success_criteriaIncreased phagocytic receptor expression, enhanced microglial recruitment and Aβ uptake, elevated LAMP2 expression and improved autophagy-lysosomal function
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:46:49.447632
source_pmid41933339
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:46:49.497707'}
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (84)
mentions📖HDAC4 Gene80%
mentions📖HDAC4 Protein80%
mentions📖LAMP2 Protein80%
mentions📖LAMP2 Protein80%
related📖HDAC4 Gene72%
related📖LAMP2 Protein72%
related📖LAMP2 Protein72%
mentions📖HDAC4 Protein70%
mentions📖LAMP2 Gene70%
related📖HDAC4 Protein63%
related📖LAMP2 Gene63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Astrocytes60%
mentions📖Astrocytes60%
mentions📖Autophagy60%
mentions📖mechanisms60%
mentions📖Microglia60%
mentions📖Microglia60%
mentions📖autophagy60%
related📖Alzheimer's Disease60%
related📖Autophagy-Lysosomal Pathway55%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Astrocytes54%
related📖Astrocytes54%
related📖Autophagy54%
related📖mechanisms54%
related📖Microglia54%
related📖Microglia54%
related📖autophagy54%
mentions📖HDAC Inhibitor Mechanism in Neurodegeneration50%
mentions📖Histone Modification Pathways in Neurodegeneration50%
mentions📖Lipid Droplet-Lysosome Axis Dysfunction Hypothesis in Parkin50%
mentions📖Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD50%
mentions📖Autophagy-Lysosomal Pathway50%
mentions📖autophagy-lysosome-dysfunction50%
mentions📖CBD Proteomics50%
mentions📖CBS Autophagy-Lysosomal Pathway Dysfunction50%
mentions📖CMA Activation Therapy Evidence Synthesis50%
mentions📖Lysosomal Dysfunction Therapeutics Investment Landscape50%
mentions📖autophagy-lysosomal-alzheimers50%
mentions📖Lysosomal Dysfunction in Neurodegeneration50%
mentions📖Chaperone-Mediated Autophagy in Neurodegeneration50%
mentions📖Lysosomal Enzyme Dysfunction Across Neurodegenerative Diseas50%
mentions📖Autophagy Types in Neurodegeneration50%
mentions📖Histone Deacetylase (HDAC) Enzymes44%
mentions📖Chromatin Remodeling and Epigenetic Therapy Synthesis for Ne44%
mentions📖Epigenetic Alterations in Alzheimer's Disease44%
mentions📖Epigenetic Dysregulation in Neurodegeneration44%
mentions📖Epigenetics in Amyotrophic Lateral Sclerosis44%
mentions📖Autophagy-Impaired Neurons44%
mentions📖Lysosomal Autophagy Neuron44%
mentions📖Lysosomal-Impaired Neurons44%
mentions📖CBS Lysosomal Dysfunction and Autophagy Impairment44%
mentions📖Endosomal Trafficking Dysfunction: Cross-Disease Comparison44%
mentions📖Mitophagy Receptor Pathway in Neurodegeneration44%
related🧫SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice40%
related🧫HDAC4 inhibition and NHE6 expression mechanism study33%
related📖HDAC4 Protein25%

💬 Discussion