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SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice

experiment Created: 2026-04-10 22:46:49 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-9260f5b8-9e2c-41e6-9a6f-f
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Related Entities
HDAC4, NHE6
Metadata
experiment_typeanimal_model
protocolAdministration of SAHA@LIPO-ANG2 nanoparticles, assessment of Aβ plaque burden, evaluation of neuroinflammation markers, synaptic protein analysis, cognitive behavioral testing
expected_outcomesReduced Aβ burden, suppressed neuroinflammation, rescued synaptic loss, improved cognitive function
success_criteriaSignificant reduction in Aβ plaques, decreased neuroinflammatory markers, restored synaptic proteins, improved performance in cognitive tests
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:46:49.447634
source_pmid41933339
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:46:49.533702'}
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Linked Artifacts (58)
mentions📖HDAC4 Gene80%
mentions📖HDAC4 Protein80%
mentions📖HDAC4 Protein80%
related📖HDAC4 Protein72%
mentions📖HDAC Inhibitors for Neurodegeneration — Investment Landscape70%
mentions📖HDAC Inhibitor Mechanism in Neurodegeneration70%
mentions📖HDAC Inhibitors70%
mentions📖HDAC Inhibitors for Neurodegenerative Diseases70%
related📖HDAC Inhibitors for Neurodegeneration — Investment Landscape63%
related📖HDAC Inhibitor Mechanism in Neurodegeneration63%
related📖HDAC Inhibitors63%
related📖HDAC Inhibitors for Neurodegenerative Diseases63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Blood-Brain Barrier60%
mentions📖Blood-Brain Barrier60%
mentions📖neuroinflammation60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Blood-Brain Barrier54%
related📖Blood-Brain Barrier54%
related📖neuroinflammation54%
mentions📖Histone Modification Pathways in Neurodegeneration50%
mentions📖Histone Deacetylase (HDAC) Enzymes44%
mentions📖Chromatin Remodeling and Epigenetic Therapy Synthesis for Ne44%
mentions📖Epigenetic Alterations in Alzheimer's Disease44%
mentions📖Epigenetic Dysregulation in Neurodegeneration44%
mentions📖Epigenetics in Amyotrophic Lateral Sclerosis44%
related🧫Neuroimmune modulation and Aβ clearance mechanisms40%
related🧫HDAC4 inhibition and NHE6 expression mechanism study40%
related📖HDAC4 Gene33%
related📖HDAC4 Protein33%
related🕸HDAC4 implicated_in neurodegeneration20%