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HDAC4 inhibition and NHE6 expression mechanism study

experiment Created: 2026-04-10 22:46:49 By: experiment_extractor Quality: 85% ✓ SciDEX ID: experiment-exp-296c7d3d-0631-464d-9fa5-4
🧫 Experiment Protocol Cell Biology
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Related Entities
HDAC4, NHE6, LRP1
Metadata
experiment_typecell_biology
protocolTreatment with SAHA@LIPO-ANG2 nanoparticles, assessment of HDAC4 nuclear translocation, measurement of NHE6 expression levels, evaluation of endosomal pH and LRP1 trafficking
expected_outcomesInhibition of HDAC4 nuclear translocation would restore NHE6 expression and normalize endosomal pH
success_criteriaReduced HDAC4 nuclear translocation, increased NHE6 expression, normalized endosomal pH, restored LRP1 plasma membrane expression
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:46:49.447623
source_pmid41933339
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:46:49.452036'}
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Linked Artifacts (64)
mentions📖HDAC4 Gene80%
mentions📖HDAC4 Protein80%
mentions📖LRP1 Gene80%
mentions📖LRP1-Enhanced Perivascular Drainage Therapy80%
mentions📖LRP1 Protein80%
related📖HDAC4 Gene72%
related📖HDAC4 Protein72%
related📖LRP1 Gene72%
related📖LRP1-Enhanced Perivascular Drainage Therapy72%
related📖LRP1 Protein72%
mentions📖HDAC4 Protein70%
mentions📖LRP1-Targeted ApoE-Mimetic Peptide Delivery70%
mentions📖LRP1-ApoE Signaling Cascade70%
mentions📖LRP1-Mediated Amyloid-Beta Clearance in Neurodegeneration70%
mentions📖LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1)70%
related📖HDAC4 Protein63%
related📖LRP1-Targeted ApoE-Mimetic Peptide Delivery63%
related📖LRP1-ApoE Signaling Cascade63%
related📖LRP1-Mediated Amyloid-Beta Clearance in Neurodegeneration63%
related📖LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1)63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Amyloid Clearance Mechanisms60%
mentions📖mechanisms60%
mentions📖researchers60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Amyloid Clearance Mechanisms54%
related📖mechanisms54%
related📖researchers54%
mentions📖HDAC Inhibitor Mechanism in Neurodegeneration50%
mentions📖Histone Modification Pathways in Neurodegeneration50%
mentions📖Histone Deacetylase (HDAC) Enzymes44%
mentions📖Chromatin Remodeling and Epigenetic Therapy Synthesis for Ne44%
mentions📖Epigenetic Alterations in Alzheimer's Disease44%
mentions📖Epigenetic Dysregulation in Neurodegeneration44%
mentions📖Epigenetics in Amyotrophic Lateral Sclerosis44%
related🧫SAHA@LIPO-ANG2 therapeutic efficacy in 5xFAD mice40%
related🧫Neuroimmune modulation and Aβ clearance mechanisms33%

💬 Discussion