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Live-cell microscopy of mitochondria-lysosome contacts and calcium dynamics

experiment Created: 2026-04-10 14:43:41 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-0aa421b5-128b-4a53-9482-f
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Related Entities
MCOLN1
Metadata
experiment_typecell_biology
protocollive-cell microscopy with calcium indicators, pharmacological modulation of TRPML1, VDAC1, and mitochondrial calcium uniporter
expected_outcomesTRPML1-mediated lysosomal calcium release should enhance mitochondrial calcium uptake at contact sites
success_criteriameasurable calcium transfer from lysosomes to mitochondria at contact sites
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T07:43:41.031585
source_pmid32703809
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T14:43:41.034157'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (18)
derives_from📄Mitochondria-lysosome contacts regulate mitochondrial Ca(2+)100%
related🧫Analysis of MLIV patient fibroblasts for contact dynamics an100%
related🧪Lysosomal Calcium Channel Modulation Therapy100%
mentions📖MCOLN1 — Mucolipin-1 (TRPML1)80%
related📖MCOLN1 — Mucolipin-1 (TRPML1)72%
mentions📖VDAC1 — Voltage Dependent Anion Channel 170%
mentions📖VDAC1 Protein70%
related📖VDAC1 — Voltage Dependent Anion Channel 163%
related📖VDAC1 Protein63%
mentions📖Mitochondria60%
mentions📖researchers60%
related🧪Lysosomal Calcium Channel Modulation Therapy60%
related📖Mitochondria54%
related📖researchers54%
mentions📖AMPK (AMP-Activated Protein Kinase)50%
mentions📖AMPK Agonist Therapy for Neurodegeneration50%
mentions📖Membrane Trafficking Pathway Dysfunction in Neurodegeneratio50%
mentions📖Lysosomal Calcium Dysregulation in Neurodegeneration50%