Live-cell microscopy of mitochondria-lysosome contacts and calcium dynamics

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active

experiment Created: 2026-04-10T14:43:41 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-0aa421b5-128b-4a53-9482-f

🧫 Experiment Protocol Cell Biologyproposed

Related Entities

MCOLN1

▸Metadata

_origin	{'url': None, 'type': 'internal', 'tracked_at': '2026-04-10T14:43:41.034157'}
p_value	None
protocol	live-cell microscopy with calcium indicators, pharmacological modulation of TRPML1, VDAC1, and mitochondrial calcium uniporter
effect_size	None
sample_size	None
source_pmid	32703809
extracted_at	2026-04-10T07:43:41.031585
_schema_version	1
experiment_type	cell_biology
success_criteria	measurable calcium transfer from lysosomes to mitochondria at contact sites
expected_outcomes	TRPML1-mediated lysosomal calcium release should enhance mitochondrial calcium uptake at contact sites
statistical_methods	None

📊 Evidence Profile Foundational

Evidence Balance

+0%

Certainty

55%

Debates

0

Incoming

11

Outgoing

10

0 supporting 0 contradicting 0 neutral

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