🧫

DEX effects on TREK-1 currents in human primary TM cells

experiment Created: 2026-04-10 03:37:12 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-167553a1-f3c4-49d4-88ee-2
🧫 Experiment Protocol Cell Biology
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Related Entities
KCNK2 (TREK-1)
Metadata
experiment_typecell_biology
protocolWhole-cell patch-clamp recording with chronic DEX treatment and ML-402 stimulation
expected_outcomesDEX would reduce TREK-1 currents and depolarize cells
success_criteriaSignificant reduction in ML-402-evoked currents and membrane depolarization
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-09T20:37:01.794571
source_pmid41268978
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T03:37:12.668352'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (8)
derives_from📄Mechano- and Glucocorticoid-Sensitive TREK-1 Channels Regula100%
related🧫TREK-1 regulation of conventional outflow facility in mouse 100%
related🧫TREK-1 effects on spontaneous OHT in rats using telemetry100%
related🧫TREK-1 localization in trabecular meshwork by immunohistoche100%
related🧫TREK-1 effects on IOP in DEX-induced mouse OHT model100%
related🧫DEX effects on K2P channel transcriptome in mouse TM cells100%
mentions📖TREK-1 Protein70%
related📖TREK-1 Protein63%