🧫

GWAS of plasma pTau217 in East Asian cohort

experiment Created: 2026-04-11 00:50:30 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-5a6f4c79-3293-4bc0-98f5-1
🧫 Experiment Protocol Genetic Association
🧫 View Full Experiment Page →
Related Entities
DACT1, DAAM1, APOE
Metadata
experiment_typegenetic_association
protocolIllumina Asian Screening Array genotyping, quality control with PLINK, removal of related individuals using KING, Hardy-Weinberg equilibrium testing, principal component analysis with PLINK2
expected_outcomesIdentification of genetic loci associated with plasma pTau217 levels, particularly expecting APOE associations given its known role in AD
success_criteriagenome-wide significance (p < 5×10^-8)
sample_size1,972
statistical_methodsgenome-wide association analysis, principal component analysis
p_valueNone
effect_sizeNone
extracted_at2026-04-10T17:50:30.814992
source_pmid41804841
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-11T00:50:30.817922'}
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Linked Artifacts (123)
experiment_target📖actg180%
mentions📖actg180%
mentions📖APOE-Expressing Astrocytes80%
mentions📖APOE Genotyping for Neurodegenerative Disease Risk Assessmen80%
mentions📖apoe80%
mentions📖APOE contributes to Alzheimer's disease by regulating b80%
mentions📖hypotheses-apoe-contributes-alzheimers-disease-regulat80%
mentions📖APOE Lipid Metabolism Pathway in Alzheimer's Disease80%
mentions📖ApoE (Apolipoprotein E)80%
produces🕸ent-gene-2a40fe25 associated_with Alzheimer's_disease80%
produces🕸ent-gene-a07c2100 associated_with Alzheimer's_disease80%
produces🕸ent-gene-6fe59a94 associated_with Alzheimer's_disease80%
related📖APOE-Expressing Astrocytes72%
related📖APOE Genotyping for Neurodegenerative Disease Risk Assessmen72%
related📖apoe72%
related📖APOE contributes to Alzheimer's disease by regulating b72%
related📖hypotheses-apoe-contributes-alzheimers-disease-regulat72%
related📖APOE Lipid Metabolism Pathway in Alzheimer's Disease72%
related📖ApoE (Apolipoprotein E)72%
mentions📖APOE Lipid Dysregulation Causal Chain in AD70%
mentions📖apoe-genotype-guided-prevention70%
mentions📖DNA Methylation Biomarkers in Neurodegeneration70%
mentions📖DNA Damage-Accumulating Neurons in Neurodegeneration70%
mentions📖DNA Damage and Repair in Neurons70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Methylation70%
mentions📖DNA Damage Repair Deficiency Validation Study in Parkinson&#70%
mentions📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 70%
mentions📖DNA Damage Repair Therapy - Biomarker Guided70%
mentions📖DNA Damage Repair Investment Landscape70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖dna-damage-repair70%
mentions📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas70%
mentions📖DNA Damage Response Impairment Pathway70%
mentions📖DNA Damage Response in 4R-Tauopathies70%
mentions📖DNA Damage Response in Alzheimer's Disease70%
mentions📖DNA Damage Response in Corticobasal Syndrome70%
mentions📖DNA Damage Response and Repair in Neurodegeneration70%
mentions📖DNA Damage Response in Neurons70%
mentions📖DNA Damage Response in Parkinson's Disease70%
mentions📖DNA Damage Response in Neurodegeneration70%
mentions📖DNA Methylation in Neurodegeneration70%
mentions📖DNA Repair Mechanisms in Neurodegeneration70%
mentions📖DNA Sensing Pathways in Neurodegeneration70%
mentions📖DNA Damage and Repair Dysfunction in PSP70%
mentions📖DNA Ligase III Protein70%
mentions📖DNA Ligase IV Protein70%
mentions📖DNA-PKcs (PRKDC) Protein70%
mentions📖DNA Damage Repair Therapy for Neurodegeneration70%
mentions📖DNA Repair Therapy for Neurodegeneration70%
mentions📖GWAS Findings Hub70%
mentions📖GWAS Findings Hub: Alzheimer's and Parkinson's Dis70%
mentions📖PET Imaging in Neurodegeneration70%
mentions📖PET Imaging Combined with Fluid Biomarkers70%
mentions📖PET Imaging for Neurodegenerative Diseases70%
related📖APOE Lipid Dysregulation Causal Chain in AD63%
related📖apoe-genotype-guided-prevention63%
related📖DNA Methylation Biomarkers in Neurodegeneration63%
related📖DNA Damage-Accumulating Neurons in Neurodegeneration63%
related📖DNA Damage and Repair in Neurons63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Methylation63%
related📖DNA Damage Repair Deficiency Validation Study in Parkinson&#63%
related📖DNA Damage Repair Deficiency Hypothesis in Parkinson's 63%
related📖DNA Damage Repair Therapy - Biomarker Guided63%
related📖DNA Damage Repair Investment Landscape63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖dna-damage-repair63%
related📖DNA Damage Repair Mechanisms Across Neurodegenerative Diseas63%
related📖DNA Damage Response Impairment Pathway63%
related📖DNA Damage Response in 4R-Tauopathies63%
related📖DNA Damage Response in Alzheimer's Disease63%
related📖DNA Damage Response in Corticobasal Syndrome63%
related📖DNA Damage Response and Repair in Neurodegeneration63%
related📖DNA Damage Response in Neurons63%
related📖DNA Damage Response in Parkinson's Disease63%
related📖DNA Damage Response in Neurodegeneration63%
related📖DNA Methylation in Neurodegeneration63%
related📖DNA Repair Mechanisms in Neurodegeneration63%
related📖DNA Sensing Pathways in Neurodegeneration63%
related📖DNA Damage and Repair Dysfunction in PSP63%
related📖DNA Ligase III Protein63%
related📖DNA Ligase IV Protein63%
related📖DNA-PKcs (PRKDC) Protein63%
related📖DNA Damage Repair Therapy for Neurodegeneration63%
related📖DNA Repair Therapy for Neurodegeneration63%
related📖GWAS Findings Hub63%
related📖GWAS Findings Hub: Alzheimer's and Parkinson's Dis63%
related📖PET Imaging in Neurodegeneration63%
related📖PET Imaging Combined with Fluid Biomarkers63%
related📖PET Imaging for Neurodegenerative Diseases63%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
produces🕸Pet associated_with Alzheimer's_disease50%
related🧫Summary-based Mendelian randomization analysis33%
related🧪Selective APOE4 Degradation via Proteolysis Targeting Chimer25%