🧫

IDH1 and IDH2 mutation sequencing in CNS and non-CNS tumors

experiment Created: 2026-04-10 22:21:12 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-5d41798b-6449-48f5-b8cd-0
🧫 Experiment Protocol Genetic Association
🧫 View Full Experiment Page →
Related Entities
IDH1, IDH2
Metadata
experiment_typegenetic_association
protocolDNA sequencing of IDH1 and IDH2 genes from tumor samples, focusing on amino acid positions 132 (IDH1) and 172 (IDH2)
expected_outcomesidentification of recurrent mutations in IDH1 and IDH2 across different glioma types and grades
success_criteriadetection of mutations and correlation with tumor grade and type
sample_size939
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:21:12.531884
source_pmid19228619
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:21:12.536334'}
🌍 Provenance Graph 2 nodes, 1 edges

derives from (1)

Linked Artifacts (55)
derives_from📄IDH1 and IDH2 mutations in gliomas.100%
related🧫Clinical outcome analysis based on IDH mutation status100%
mentions📖IDH1 Gene - Isocitrate Dehydrogenase 180%
related📖IDH1 Gene - Isocitrate Dehydrogenase 172%
mentions📖CNS Border-Associated Macrophages (BAMs)70%
mentions📖CNS Vasculitis70%
mentions📖CNS-Selective NLRP3 Inflammasome Inhibitor70%
mentions📖CNS Drug Delivery Methods70%
mentions📖CNS Lymphatic and Meningeal Immunity in 4R-Tauopathies70%
mentions📖IDH1 Protein - Isocitrate Dehydrogenase 170%
mentions📖idh270%
related📖CNS Border-Associated Macrophages (BAMs)63%
related📖CNS Vasculitis63%
related📖CNS-Selective NLRP3 Inflammasome Inhibitor63%
related📖CNS Drug Delivery Methods63%
related📖CNS Lymphatic and Meningeal Immunity in 4R-Tauopathies63%
related📖IDH1 Protein - Isocitrate Dehydrogenase 163%
related📖idh263%
mentions📖Epigenetic Biomarkers in Neurodegenerative Diseases50%
mentions📖Epigenetic Clocks in Neurodegeneration — Causal Drivers or P50%
mentions📖Epigenetic Dysregulation in Huntington's Disease — Ther50%
mentions📖Epigenetic Dysregulation Validation in Parkinson's Dise50%
mentions📖Epigenetic Regulation Dysfunction in Alzheimer's and Pa50%
mentions📖Epigenetic Clock Reversal Therapy for Neurodegeneration Prev50%
mentions📖Wnt Pathway Modulation for Synaptic Resilience50%
mentions📖Epigenetic Therapy in Neurodegeneration: Investment Landscap50%
mentions📖Wnt Signaling Therapeutics: Investment Landscape Analysis50%
mentions📖Epigenetic Changes in Progressive Supranuclear Palsy50%
mentions📖Wnt Signaling Dysfunction in Neurodegenerative Diseases50%
mentions📖Epigenetic Therapies for Neurodegeneration50%
mentions📖Wnt Signaling Modulation Therapy50%
mentions📖Cerebellar Interneurons in Neurodegeneration50%
mentions📖Medial Forebrain Bundle in Neurodegeneration50%
mentions📖Ventral Tegmental Area Dopamine Neurons in Neurodegeneration50%
mentions📖Sirtuin Pathway Dysfunction Hypothesis in Parkinson's D50%
mentions📖Sirtuin-Mitochondrial Biogenesis Axis in Neurodegeneration50%
mentions📖Sirtuin Signaling in 4R-Tauopathies50%
mentions📖Sirtuin Signaling in Neurodegeneration50%
mentions📖Sirtuin Signaling Pathway50%
mentions📖Section 186: Bioenergetics and Mitochondrial Coupling Therap50%
mentions📖Section 194: Advanced Mitochondrial Dynamics and Biogenesis 50%
mentions📖Sirtuin Signaling in Parkinson's Disease50%
mentions📖Section 194: Advanced Mitochondrial Dynamics and Biogenesis 50%
mentions📖Sirtuin Modulators for Parkinson's Disease50%
mentions📖Sirtuin Modulators50%
mentions📖DNA Methylation44%
mentions📖Citric Acid Cycle (TCA Cycle)44%
mentions📖Thioflavin-T Fluorescence Assay for Protein Aggregation44%
mentions📖Entorhinal Cortex44%
mentions📖Entorhinal Cortex Layer II Neurons44%
mentions📖Entorhinal Cortex Layer II44%
mentions📖Entorhinal Cortex Layer II Neurons44%
mentions📖Lateral Superior Olive (LSO) Neurons44%
mentions📖Medial Nucleus of the Trapezoid Body (MNTB) Neurons44%
mentions📖Trapezoid Body Complex44%

💬 Discussion