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SIRPα modulation in mouse models of Alzheimer's disease

experiment Created: 2026-04-10 23:10:58 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-5f00f670-82a1-480f-8e41-6
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SIRPα
Metadata
experiment_typeanimal_model
protocolModulation of microglial SIRPα expression in Alzheimer's disease mouse models followed by assessment of synaptic loss, microglial engulfment activity, and cognitive testing
expected_outcomesLoss of microglial SIRPα results in increased synaptic loss, enhanced microglial engulfment, and worsened cognitive impairment
success_criteriaSignificant increases in synaptic loss and cognitive deficits in mice with reduced microglial SIRPα
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T16:10:58.597427
source_pmid33795678
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T23:10:58.701982'}
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Linked Artifacts (39)
related🧫Microglia-specific SIRPα deletion in conditional knockout mi100%
related🧫Microglial SIRPα expression in human Alzheimer's diseas100%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
mentions📖Preclinical Alzheimer's Disease60%
mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN1 Mutations in Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Microglia60%
mentions📖Microglia60%
mentions📖Neurodegeneration60%
mentions📖researchers60%
related📖Alzheimer's Disease60%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN1 Mutations in Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Microglia54%
related📖Microglia54%
related📖Neurodegeneration54%
related📖researchers54%