🧫

Adoptive transfer of TCRAβ-Tregs in AD mouse model

experiment Created: 2026-04-10 22:51:28 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-94b13181-2a62-4f75-ae37-d
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Related Entities
APP, PSEN1
Metadata
experiment_typeanimal_model
protocolAdoptive transfer of TCRAβ-Tregs followed by behavioral testing, immunohistochemistry, and 18F-FDG tracking
expected_outcomesReduced amyloid burden, decreased neuroinflammation, improved cognitive function
success_criteriaSignificant reduction in amyloid load and improved performance on cognitive tests
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T15:51:28.492760
source_pmid38111016
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-10T22:51:28.567965'}
🌍 Provenance Graph 1 nodes, 0 edges

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Linked Artifacts (167)
mentions📖APP-Overexpressing Neurons80%
mentions📖APP Arctic Mutation (APP Arctic)80%
mentions📖APP Dutch Mutation (APP Dutch)80%
mentions📖APP Flemish Mutation (APP Flemish)80%
mentions📖APP Swedish Mutation (APPswe)80%
mentions📖APP Gene80%
mentions📖app80%
mentions📖APP Gene Dosage Reduction Therapy for Down Syndrome80%
mentions📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai80%
mentions📖APP Amyloid Pathway in Alzheimer's Disease80%
mentions📖APP-BACE1-Fe65 Complex80%
mentions📖APP Processing and Amyloid-Beta Production80%
mentions📖APP/PS1 Double Transgenic Mouse Model80%
mentions📖APP/PS1 Dual Transgenic Mouse Model80%
mentions📖APP Protein80%
mentions📖PSEN1-Mutant Neurons80%
mentions📖PSEN1 Mutations in Alzheimer's Disease80%
mentions📖entities-psen180%
mentions📖PSEN1 — Presenilin 180%
mentions📖PSEN1 Presenilin 1 AD Causal Chain80%
mentions📖PSEN1 Protein (Presenilin-1)80%
related📖APP-Overexpressing Neurons72%
related📖APP Arctic Mutation (APP Arctic)72%
related📖APP Dutch Mutation (APP Dutch)72%
related📖APP Flemish Mutation (APP Flemish)72%
related📖APP Swedish Mutation (APPswe)72%
related📖APP Gene72%
related📖APP Gene Dosage Reduction Therapy for Down Syndrome72%
related📖APP→Amyloid-beta→Plaque→Alzheimer's Disease Causal Chai72%
related📖APP Amyloid Pathway in Alzheimer's Disease72%
related📖APP-BACE1-Fe65 Complex72%
related📖APP Processing and Amyloid-Beta Production72%
related📖APP/PS1 Double Transgenic Mouse Model72%
related📖APP/PS1 Dual Transgenic Mouse Model72%
related📖APP Protein72%
related📖PSEN1-Mutant Neurons72%
related📖PSEN1 Mutations in Alzheimer's Disease72%
related📖entities-psen172%
related📖PSEN1 — Presenilin 172%
related📖PSEN1 Presenilin 1 AD Causal Chain72%
related📖PSEN1 Protein (Presenilin-1)72%
mentions📖Agitation in Alzheimer's Disease60%
mentions📖Alzheimer's Disease60%
mentions📖Alzheimer's Disease Genetic Variants60%
mentions📖Alzheimer's Disease vs Parkinson's Disease Compari60%
mentions📖APP Mutations in Alzheimer's Disease60%
mentions📖DLB, Parkinson's Disease, and Alzheimer's Disease:60%
mentions📖Early-Onset Alzheimer's Disease (EOAD)60%
mentions📖Investment Landscape: Alzheimer's Disease60%
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mentions📖Prodromal Alzheimer's Disease60%
mentions📖PSEN2 Mutations in Alzheimer's Disease60%
mentions📖Sporadic vs Familial Alzheimer's Disease: Comprehensive60%
mentions📖TREM2 Variants in Alzheimer's Disease60%
mentions📖Microglia60%
mentions📖Microglia60%
mentions📖presenilin-160%
related📖Alzheimer's Disease60%
related📖neuroinflammation55%
related📖Agitation in Alzheimer's Disease54%
related📖Alzheimer's Disease54%
related📖Alzheimer's Disease Genetic Variants54%
related📖Alzheimer's Disease vs Parkinson's Disease Compari54%
related📖APP Mutations in Alzheimer's Disease54%
related📖DLB, Parkinson's Disease, and Alzheimer's Disease:54%
related📖Early-Onset Alzheimer's Disease (EOAD)54%
related📖Investment Landscape: Alzheimer's Disease54%
related📖Preclinical Alzheimer's Disease54%
related📖Prodromal Alzheimer's Disease54%
related📖PSEN2 Mutations in Alzheimer's Disease54%
related📖Sporadic vs Familial Alzheimer's Disease: Comprehensive54%
related📖TREM2 Variants in Alzheimer's Disease54%
related📖Microglia54%
related📖Microglia54%
related📖presenilin-154%
mentions📖Amyloid Cascade Pathway50%
mentions📖remternetug-sc-genetic-ad-nct0555215750%
mentions📖5xFAD Transgenic Mouse Model50%
mentions📖Presenilin-1 (PS1)50%
mentions📖PSEN2 Presenilin 2 AD Causal Chain50%
mentions📖DIAN-TU-001 Trial (NCT01760005)50%
mentions📖genetics50%
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mentions📖Amyloid Beta 40 (Aβ40) - Biomarker50%
mentions📖NYSCF Scientific Discovery Biobank (NCT06203106)50%
mentions📖Tauopathies Comparison Matrix50%
mentions📖Amyloid Precursor Protein (APP)50%
mentions📖DIAN-Observational Study (DIAN-O)50%
mentions📖Neuritic Amyloid Plaques — Histomorphologic Evidence of Path50%
mentions📖AAV-Delivered RNA Targeting Therapy for Neurodegeneration50%
mentions📖AD Experimental Models Scorecard50%
mentions📖Shared Mechanisms Between Alzheimer and Parkinson Disease50%
mentions📖Amyloid-Beta Aggregation and Plaque Formation50%
mentions📖Amyloid-beta Fibril Formation Pathway50%
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mentions📖Autophagy-Lysosomal Impairment Comparison — AD/PD/ALS/FTD/HD50%
mentions📖Calcium Dysregulation in Neurodegenerative Diseases50%
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mentions📖Circadian Rhythm in Neurodegeneration50%
mentions📖Notch Signaling Pathway in Neurodegeneration50%
mentions📖SORL1→APP Trafficking→Retromer Dysfunction→Aβ Accumulation→A50%
mentions📖Dominantly Inherited Alzheimer Network (DIAN) Dataset50%
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mentions📖Amyloid vs Tau-First Hypothesis50%
mentions📖Amyloid vs Tau-First Hypothesis in Alzheimer's Disease50%
mentions📖Calcium Dysregulation in Alzheimer's Disease50%
mentions📖Endolysosomal Pathway in Alzheimer's Disease50%
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mentions📖amyloid-cascade-hypothesis50%
mentions📖Autophagy-Lysosomal Impairment Across Neurodegenerative Dise50%
mentions📖Dominantly Inherited Alzheimer Network (DIAN)50%
mentions📖5xFAD Transgenic Mouse Model50%
mentions📖Etalanetug (E2814)50%
mentions📖3xtg-ad-mouse50%
mentions📖Gene-Mechanism-Therapy Causal Chains50%
mentions📖3xTG-AD Triple Transgenic Mouse Model50%
mentions📖Alzheimer Hippocampal Circuit50%
mentions📖adpd-2026-precision-medicine-genetic-stratification50%
mentions📖PSEN2-Mutant Neurons50%
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mentions📖Tau-Seed Interception Using Conformational-Selective Extrace44%
mentions📖Notch Signaling Modulation Therapy for Neurodegeneration44%
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mentions📖Blood p-Tau217 as a Clock for Alzheimer's Disease Onset44%
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mentions📖mechanisms-er-mitochondria-contact-sites44%
mentions📖ER Stress and Unfolded Protein Response in Neurodegeneration44%
mentions📖Membrane Trafficking Pathway Dysfunction in Neurodegeneratio44%
mentions📖Nanomedicine for Alzheimer's Disease44%
mentions📖Pretangle in Neurodegeneration44%
mentions📖Protein Aggregation Comparison in Neurodegeneration44%
mentions📖Mechanism Rankings44%
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mentions📖Tau Consortium44%
mentions📖What to Work On — NeuroWiki Decision Guide44%
mentions📖CRISPR-Cas9 Gene Editing for Neurodegenerative Diseases44%
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mentions📖ESM (Evolutionary Scale Modeling)44%
mentions📖Etalanetug (E2814)44%
mentions📖CRISPR Gene Editing for Neurodegeneration44%
mentions📖NACET (N-Acetylcysteine Ethyl Ester)44%
related📜Test Paper: Understanding Alzheimer Disease Mechanisms40%
related🧫Creation and validation of 3xAD-ChAT-Cre mouse model33%
related📖app33%