🧫

Bmal1 knockout in mPFC excitatory neurons

experiment Created: 2026-04-11 00:49:32 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-c37c2209-0e35-4e18-95d5-5
🧫 Experiment Protocol Animal Model
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Related Entities
BMAL1,HOMER1A,CAMK2A
Metadata
experiment_typeanimal_model
protocolStereotaxic viral injection for Bmal1 deletion in mPFC CaMK2a+ neurons, sleep monitoring, behavioral testing, molecular analysis
expected_outcomesDisrupted sleep homeostasis and abolished antidepressant response to sleep deprivation
success_criteriaComplete elimination of SD behavioral and molecular effects in Bmal1 knockout mice
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T17:49:32.189585
source_pmid41023421
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-11T00:49:32.250853'}
🌍 Provenance Graph 1 nodes, 0 edges

No provenance edges found

Linked Artifacts (15)
mentions📖BMAL1 (ARNTL) Gene80%
mentions📖BMAL1 Protein80%
mentions📖CAMK2A Gene80%
mentions📖CaMKII Protein (CaMK2A)80%
related📖BMAL1 Protein72%
mentions📖Depression (Major Depressive Disorder)60%
mentions📖CLOCK Gene60%
related📖Depression (Major Depressive Disorder)60%
related📖Depression (Major Depressive Disorder)54%
related📖CLOCK Gene54%
related🧪Circadian Rhythm Entrainment of Reactive Astrocytes25%
related📖BMAL125%
related📖BMAL1 (ARNTL) Gene25%
related📖CAMK2A Gene25%
related📖CaMKII Protein (CaMK2A)25%