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Long-term perampanel treatment in A53T BAC-SNCA mice with PFF injection

experiment Created: 2026-04-11 00:48:31 By: experiment_extractor Quality: 95% ✓ SciDEX ID: experiment-exp-e67da95a-fc6f-457a-9743-1
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Related Entities
SNCA
Metadata
experiment_typeanimal_model
protocolPFF injection followed by perampanel or vehicle treatment for 2 and 9 months, with assessment of pathology in different brain regions
expected_outcomesreduced α-synuclein pathology in distant regions and ameliorated neurodegeneration with perampanel treatment
success_criteriasignificant reduction in pathology spread to second/higher-order regions and reduced neurodegeneration
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T17:48:31.406292
source_pmid41508763
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-11T00:48:31.534038'}
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Linked Artifacts (27)
related🧫PFF clearance kinetics in Snca knockout mice100%
related🧫Dexamethasone treatment study in α-synuclein mice100%
related🧫PFF uptake in primary hippocampal neurons with inhibitors100%
mentions📖SNCA-A53T Alpha-Synuclein Neurons80%
mentions📖SNCA-Overexpressing Dopaminergic Neurons80%
mentions📖SNCA A53T80%
mentions📖SNCA Gene Variants and Mutations80%
mentions📖SNCA — Alpha-Synuclein80%
mentions📖SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathi80%
mentions📖snca-protein80%
related📖SNCA-A53T Alpha-Synuclein Neurons72%
related📖SNCA-Overexpressing Dopaminergic Neurons72%
related📖SNCA A53T72%
related📖SNCA Gene Variants and Mutations72%
related📖SNCA — Alpha-Synuclein72%
related📖SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathi72%
related📖snca-protein72%
mentions📖A53T Alpha-Synuclein Transgenic Mouse Model of Parkinson70%
mentions📖SNCA — Alpha-Synuclein Gene Entity Page70%
mentions📖SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain70%
related📖A53T Alpha-Synuclein Transgenic Mouse Model of Parkinson63%
related📖SNCA — Alpha-Synuclein Gene Entity Page63%
related📖SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain63%
mentions📖brain-regions60%
mentions📖Neurodegeneration60%
related📖brain-regions54%
related📖Neurodegeneration54%