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PFF uptake in primary hippocampal neurons with inhibitors

experiment Created: 2026-04-11 00:48:31 By: experiment_extractor Quality: 90% ✓ SciDEX ID: experiment-exp-dbfdb26b-4a5f-463a-8a23-9
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Related Entities
SNCA
Metadata
experiment_typecell_biology
protocolPFFs labeled with pH-sensitive dye were applied to cultured neurons, with treatment using dynamin or clathrin inhibitors
expected_outcomesPFF uptake would be blocked by dynamin inhibitors but not clathrin inhibitors
success_criteriasignificant reduction in PFF uptake with dynamin inhibition
sample_sizeNone
statistical_methodsNone
p_valueNone
effect_sizeNone
extracted_at2026-04-10T17:48:31.406278
source_pmid41508763
_origin{'type': 'internal', 'url': None, 'tracked_at': '2026-04-11T00:48:31.411165'}
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Linked Artifacts (25)
related🧫PFF clearance kinetics in Snca knockout mice100%
related🧫Dexamethasone treatment study in α-synuclein mice100%
related🧫Long-term perampanel treatment in A53T BAC-SNCA mice with PF100%
mentions📖SNCA-A53T Alpha-Synuclein Neurons80%
mentions📖SNCA-Overexpressing Dopaminergic Neurons80%
mentions📖SNCA A53T80%
mentions📖SNCA Gene Variants and Mutations80%
mentions📖SNCA — Alpha-Synuclein Gene Entity Page80%
mentions📖SNCA — Alpha-Synuclein80%
mentions📖SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathi80%
mentions📖SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain80%
mentions📖snca-protein80%
related📖SNCA-A53T Alpha-Synuclein Neurons72%
related📖SNCA-Overexpressing Dopaminergic Neurons72%
related📖SNCA A53T72%
related📖SNCA Gene Variants and Mutations72%
related📖SNCA — Alpha-Synuclein Gene Entity Page72%
related📖SNCA — Alpha-Synuclein72%
related📖SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathi72%
related📖SNCA→Alpha-synuclein→Parkinson's Disease Causal Chain72%
related📖snca-protein72%
mentions📖Hippocampal Neurons60%
mentions📖mechanisms60%
related📖Hippocampal Neurons54%
related📖mechanisms54%