TFUS-Gamma Entrainment Synergizes with Anti-Amyloid Immunotherapy

graph TD
    CCK_basket_cells["CCK basket cells"] -->|regulates| pyramidal_cell_synchroniz["pyramidal cell synchronization"]
    sharp_wave_ripple_gamma_c["sharp-wave ripple-gamma coupling"] -->|associated with| memory_consolidation["memory consolidation"]
    PV_interneurons["PV interneurons"] -->|activates| gamma_oscillation_generat["gamma oscillation generation"]
    Hippocampal_gamma_oscilla["Hippocampal gamma oscillations"] -->|causes| n5xFAD_mice_AD_model["5xFAD mice AD model"]
    n40_Hz_gamma_entrainment["40 Hz gamma entrainment"] -->|prevents| amyloid_beta_accumulation["amyloid-beta accumulation"]
    n40_Hz_gamma_entrainment_1["40 Hz gamma entrainment"] -->|prevents| tau_pathology["tau pathology"]
    CB1_expressing_interneuro["CB1-expressing interneurons"] -->|regulates| sharp_wave_ripple_timing["sharp-wave ripple timing"]
    closed_loop_TFUS["closed-loop TFUS"] -->|modulates| hippocampal_network_oscil["hippocampal network oscillations"]
    CA3_CA1_pyramidal_network["CA3-CA1 pyramidal networks"] -->|causes| sharp_wave_ripple_generat["sharp-wave ripple generation"]
    PV_interneurons_2["PV interneurons"] -->|activates| sharp_wave_ripple_generat_3["sharp-wave ripple generation"]
    closed_loop_hippocampal_T["closed-loop hippocampal TFUS"] -->|therapeutic target| early_Alzheimer_s_disease["early Alzheimer's disease"]
    n40_Hz_stimulation["40 Hz stimulation"] -->|activates| sharp_wave_ripple_events_["sharp-wave ripple events during NREM sleep"]
    style CCK_basket_cells fill:#4fc3f7,stroke:#333,color:#000
    style pyramidal_cell_synchroniz fill:#4fc3f7,stroke:#333,color:#000
    style sharp_wave_ripple_gamma_c fill:#4fc3f7,stroke:#333,color:#000
    style memory_consolidation fill:#4fc3f7,stroke:#333,color:#000
    style PV_interneurons fill:#4fc3f7,stroke:#333,color:#000
    style gamma_oscillation_generat fill:#4fc3f7,stroke:#333,color:#000
    style Hippocampal_gamma_oscilla fill:#4fc3f7,stroke:#333,color:#000
    style n5xFAD_mice_AD_model fill:#ef5350,stroke:#333,color:#000
    style n40_Hz_gamma_entrainment fill:#4fc3f7,stroke:#333,color:#000
    style amyloid_beta_accumulation fill:#4fc3f7,stroke:#333,color:#000
    style n40_Hz_gamma_entrainment_1 fill:#4fc3f7,stroke:#333,color:#000
    style tau_pathology fill:#4fc3f7,stroke:#333,color:#000
    style CB1_expressing_interneuro fill:#4fc3f7,stroke:#333,color:#000
    style sharp_wave_ripple_timing fill:#4fc3f7,stroke:#333,color:#000
    style closed_loop_TFUS fill:#4fc3f7,stroke:#333,color:#000
    style hippocampal_network_oscil fill:#4fc3f7,stroke:#333,color:#000
    style CA3_CA1_pyramidal_network fill:#4fc3f7,stroke:#333,color:#000
    style sharp_wave_ripple_generat fill:#4fc3f7,stroke:#333,color:#000
    style PV_interneurons_2 fill:#4fc3f7,stroke:#333,color:#000
    style sharp_wave_ripple_generat_3 fill:#4fc3f7,stroke:#333,color:#000
    style closed_loop_hippocampal_T fill:#4fc3f7,stroke:#333,color:#000
    style early_Alzheimer_s_disease fill:#ef5350,stroke:#333,color:#000
    style n40_Hz_stimulation fill:#4fc3f7,stroke:#333,color:#000
    style sharp_wave_ripple_events_ fill:#4fc3f7,stroke:#333,color:#000