concept

AMYLOID-BETA ACCUMULATION

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about AMYLOID-BETA ACCUMULATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections

0Hypotheses

6Analyses

5Outgoing

21Incoming

0Experiments

17Debates

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💡 Concept Info

Name	AMYLOID-BETA ACCUMULATION
Key Genes/Proteins	AQP4

Pathway Diagram

graph TD
    AMYLOID_BETA_ACCUMULATION[AMYLOID-BETA ACCUMULATION]
    AMYLOID_BETA_ACCUMULATION -->|contributes to| Alzheimer_Disease[Alzheimer Disease]
    AMYLOID_BETA_ACCUMULATION -->|contributes to| Alzheimer_s_Disease[Alzheimer's Disease]
    AMYLOID_BETA_ACCUMULATION -->|contributes to| Sulfatide_Loss[Sulfatide Loss]
    Apoe4[Apoe4] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    Autophagy_Clearance_Failure[Autophagy Clearance Failure] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    Glymphatic_System_Impairment[Glymphatic System Impairment] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    APOE[APOE] -->|promotes| AMYLOID_BETA_ACCUMULATION
    Complement_System[Complement System] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    APP_PSEN1[APP/PSEN1] -->|causes| AMYLOID_BETA_ACCUMULATION
    SIK2[SIK2] -.prevents.-> AMYLOID_BETA_ACCUMULATION
    GLYMPHATIC_SYSTEM_IMPAIRMENT[GLYMPHATIC SYSTEM IMPAIRMENT] -->|contributes to| AMYLOID_BETA_ACCUMULATION
    TET2[TET2] -->|inhibits| AMYLOID_BETA_ACCUMULATION
    AQP4[AQP4] -->|regulates| AMYLOID_BETA_ACCUMULATION

Outgoing (5)

Target	Relation	Type	Str
Alzheimer Disease	contributes_to	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.95
Alzheimer's Disease	causes	disease	0.95
Alzheimer's Disease	contributes_to	disease	0.90
Sulfatide Loss	contributes_to	phenotype	0.80

Incoming (21)

Source	Relation	Type	Str
Autophagy Clearance Failure	contributes_to	process	0.90
SIK2	prevents	gene	0.90
Glymphatic System Impairment	contributes_to	process	0.90
31690660	increased	paper	0.90
Complement System	contributes_to	pathway	0.90
Apoe4	contributes_to	biomarker	0.90
APOE	promotes	gene	0.90
APP/PSEN1	causes	gene	0.90
GLYMPHATIC SYSTEM IMPAIRMENT	contributes_to	process	0.89
AQP4	regulates	protein	0.88
TET2	inhibits	gene	0.88
TET2 Reduction	contributes_to	process	0.87
Glymphatic System	associated_with	process	0.80
APOE	therapeutic_target	gene	0.75
microglial senescence	causes	process	0.70
40 Hz gamma entrainment	prevents	process	0.70
lipid raft remodeling	prevents	process	0.70
CYP46A1	reduces	gene	0.70
sleep deprivation	causes	process	0.70
TFEB overexpression	reduces	gene	0.70
myelin dysfunction	causes	phenotype	0.50