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Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
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ID: paper-22343897
📄 Paper Details
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.
["Ichimura A", "Hirasawa A", "Poulain-Godefroy O", "Bonnefond A", "Hara T", "Yengo L", "Kimura I", "Leloire A", "Liu N", "Iida K"]
Abstract
Free fatty acids provide an important energy source as nutrients, and act as signalling molecules in various cellular processes. Several G-protein-coupled receptors have been identified as free-fatty-acid receptors important in physiology as well as in several diseases. GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role in various physiological homeostasis mechanisms such as adipogenesis, regulation of appetite and food prefe...
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📊 Evidence Profile
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