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Potent and specific MTH1 inhibitors targeting gastric cancer.
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ID: paper-31164636
📄 Paper Details
Potent and specific MTH1 inhibitors targeting gastric cancer.
["Zhou W", "Ma L", "Yang J", "Qiao H", "Li L", "Guo Q", "Ma J", "Zhao L", "Wang J", "Jiang G"]
Abstract
Human mutT homolog 1(MTH1), the oxidized dNTP pool sanitizer enzyme, has been reported to be highly expressed in various malignant tumors. However, the oncogenic role of MTH1 in gastric cancer remains to be determined. In the current study, we found that MTH1 was overexpressed in human gastric cancer tissues and cells. Using an in vitro MTH1 inhibitor screening system, the compounds available in our laboratory were screened and the small molecules containing 5-cyano-6-phenylpyrimidine structure ...
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