📄
Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-41841574
📄 Paper Details
Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4- and VEGF-mediated pathways: insights from a vascular to mixed-type dementia model.
["Jia-Hung Chen", "Ching-Wen Chang", "You-Yin Chen", "Chih-Hao Yang", "Wen-Bin Yang", "Yi-Chen Hsieh", "Yao-Wen Liang", "Ssu-Ju Li", "Chaur-Jong Hu"]
Abstract
INTRODUCTION: Chronic cerebral hypoperfusion (CCH) is a major contributor to cognitive impairment; however, its underlying mechanisms remain poorly understood. METHODS: We investigated CCH-induced glymphatic dysfunction and neurodegeneration in amyloid precursor protein (APP)/presenilin 1 (PS1) and wild-type mice. Glymphatic transport was assessed using contrast-enhanced magnetic resonance imaging (MRI) and real-time femoral vein imaging. Aquaporin-4 (AQP4) polarization and amyloid beta (Aβ)/pho...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.