📄
Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma.
active
paper
Created:
By: unknown
Quality:
50%
✓ SciDEX
ID: paper-41946693
📄 Paper Details
Activation of Nerve Growth Factor signaling limits the response to lenvatinib in hepatocellular carcinoma.
Xu M, Zheng Y, Zhao L, Wang S, Chen J et al.
Abstract
Resistance to lenvatinib remains a major barrier in the treatment of advanced hepatocellular carcinoma (HCC), underscoring the urgent need to elucidate the underlying mechanisms and identify actionable therapeutic targets. In this study, we identified a neurosecretory factor derived from HCC cells, Nerve Growth Factor (NGF), as a critical mediator of lenvatinib resistance. Utilizing an innovative in vivo-in vitro cross-circulated strategy, we established a phenotypically stable lenvatinib-resist...
▸Metadata
| _schema_version | 1 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.