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Extended Data Fig. 6: scRNA-seq and translatome analysis of perivascular cells and microglia. (a) UMA...
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Created: 2026-04-15T23:28:06
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ID: paper-fig-36747024-11
Extended Data Fig. 6Figure 11
scRNA-seq and translatome analysis of perivascular cells and microglia. (a) UMAP plot of 4,238 cells, color-coded based on the inferred cell type. (b) DotPlot of gene expression for a series of known cell type markers for fibroblasts ( Lama1, Lum, Cdh5, Dcn ), microglia ( Sall1, Tmem119, P2ry12 ), PVMs ( Pf4, Cd163 ), and OPC ( Lhfpl3, Sox6, Bcan ). Expression of genes encoding for markers used for FACS of cells prior to scRNA-seq ( Pdgfra, Ptprc, Itgam, Mrc1, Cx3cr1 ) and for Spp1 is also included. Radius of dot is proportional to the percentage of cells expressing the gene, color is the scaled gene expression level. (c) Violin plot of Spp1 expression reanalyzed from Jung-Seok Kim et al. 11 . (d) RiboTag-based translatome analysis of pooled oAβ and PBS-challenged brain homogenates of Cx3cr1 ccre :Lyve1 ncre (n = 8 mice) and Cx3cr1 ccre Sall1 ncre :RiboTag-mice (n = 4 mice). Normalized reads of pan macrophage marker ( Cx3cr1 ), PVM marker ( Lyve1 ), microglia marker ( Sal
▸Metadata
| doi | |
| pmcid | PMC9991912 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig11_ESM.jpg', 'type': 'external', 'tracked_at': '2026-04-15T23:28:06.351659'} |
| caption | scRNA-seq and translatome analysis of perivascular cells and microglia. (a) UMAP plot of 4,238 cells, color-coded based on the inferred cell type. (b) DotPlot of gene expression for a series of kno |
| paper_id | 36747024 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9991912/bin/41593_2023_1257_Fig11_ESM.jpg |
| image_path | |
| description | |
| figure_label | Extended Data Fig. 6 |
| figure_number | 11 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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