Complement C1q Subtype Switching

**Molecular Mechanism and Rationale** The complement C1q complex represents a critical nexus in neuroinflammation and astrocyte-mediated pathology in neurodegenerative diseases. This trimeric protein complex consists of three distinct subunits—C1qA, C1qB, and C1qC—that assemble in varying stoichiometric ratios to form heterotrimeric complexes with distinct functional properties. In healthy neural tissue, C1q complexes maintain homeostatic balance between immune surveillance and neuroprotection....