Fig. 5: Spp1 regulates perivascular–microglial interaction networks. a , Expression lev...

Spp1 regulates perivascular–microglial interaction networks. a , Expression level of selected ligands expressed by cell types known to express Spp1 (PVF and PVM), by cell type and genotype. Radius of dot is proportional to the percentage of cells expressing the gene; color is the scaled gene expression level. b , Predicted receptor genes for ligands represented in a , which show differential expression in microglia (receiver cells). Color represents the predicted interaction potential. c , Predicted target genes downstream of receptors identified in b , which show differential expression in microglia (receiver cells). Color represents the predicted regulatory potential. d , Expression of predicted receptor genes in microglia, by genotype. Radius of dot is proportional to the percentage of cells expressing the gene; color is the scaled gene expression level. e , Quantification of Tgfbr1 and Itgb5 mRNA levels expressed by P2Y12 + microglia assessed by smFISH-IHC in 6-month

extracted_from