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Fig. 7: Functional validation of predicted phenotypic plasticity upon chemotherapy. A A...
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Fig. 7Figure 7
Functional validation of predicted phenotypic plasticity upon chemotherapy. A Analysis of PAX8 mRNA expression, influence and relative protein expression in U87MG, U87MG-R50, and U87MG-OFF. Top panel: Representative Western blot (WB) detection of PAX8 protein and its predicted activity based on the regulatory network (colored dots under the WB), along with quantitative analysis ( n > 3) of its relative protein level. Unprocessed scans of the WB are provided in Supplementary Fig. 3 . Bottom panel: mRNA expression and influence barplots of PAX8 and detection of the PAX8 protein by immunofluorescence in the same samples analyzed by WB. B mRNA expression levels of NKX2.5 in primary and recurrent gliomas, as analyzed using the Chinese Glioma Genome Atlas (CGGA, http://www.cgga.org.cn/index.jsp ) cohort. NKX2.5 expression is significantly higher in grade IV gliomas compared to grade III and grade II gliomas. C Survival analysis of recurrent GBM patients (grade IV) based on NKX2.5 exp
▸Metadata
| doi | 10.1038/s41698-025-00890-0 |
| pmcid | PMC12000621 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12000621/bin/41698_2025_890_Fig7_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:18.179003'} |
| caption | Functional validation of predicted phenotypic plasticity upon chemotherapy. A Analysis of PAX8 mRNA expression, influence and relative protein expression in U87MG, U87MG-R50, and U87MG-OFF. Top panel |
| paper_id | 632e2e73-56b1-4816-8c3f-2c9f1dc97082 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12000621/bin/41698_2025_890_Fig7_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 7 |
| figure_number | 7 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
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