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Fig. 4: ZFP64 directly bound to the promoters of GCH1 and FTH1 to promote their transcri...
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Created: 2026-04-22T18:08:29
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ID: paper-fig-707e4dfb-3896-4244-8e2a-7a749d
Fig. 4Figure 4
ZFP64 directly bound to the promoters of GCH1 and FTH1 to promote their transcription. ( A ) Expression levels of ferroptosis-related molecules in TNBC cells were detected by RT-qPCR after transfection with shNC or shZFP64 for 48 h. ( B ) FTH1 level in DOX-resistant/sensitive TNBC tissues was evaluated by RT-qPCR. ( C ) Pearson correlation test detected the correlation between ZFP64 and FTH1 levels in DOX-resistant TNBC tissues. ( D ) RT-qPCR analysis of GCH1 level in DOX-resistant/sensitive TNBC tissues. ( E ) Pearson correlation test evaluated the correlation between ZFP64 and GCH1 levels in DOX-resistant TNBC tissues. ( F & G ) GCH1 and FTH1 expression was measured by RT-qPCR and Western blotting in DOX-treated TNBC cells co-cultured with or without CAF/R together with or without transfection with shNC or shZFP64. ( H - J ) JASPAR database predicted the potential binding sites of ZFP64 to GCH1 or FTH1 promoter. ( K ) The direct binding of ZFP64 to GCH1 or FTH1 promoter in TNBC cells
▸Metadata
| doi | 10.1186/s12967-025-06246-3 |
| pmcid | PMC11871786 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig4_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:29.148225'} |
| caption | ZFP64 directly bound to the promoters of GCH1 and FTH1 to promote their transcription. ( A ) Expression levels of ferroptosis-related molecules in TNBC cells were detected by RT-qPCR after transfectio |
| paper_id | 707e4dfb-3896-4244-8e2a-7a749d45b168 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig4_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 4 |
| figure_number | 4 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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