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Fig. 5: FTH1 or GCH1 overexpression abolished shZFP64-mediated promotion in ferroptosis ...
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Created: 2026-04-22T18:08:29
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ID: paper-fig-707e4dfb-3896-4244-8e2a-7a749d
Fig. 5Figure 5
FTH1 or GCH1 overexpression abolished shZFP64-mediated promotion in ferroptosis and DOX sensitivity in TNBC cells. ( A - D ) TNBC cells were transfected with vector, FTH1 or GCH1 overexpressing plasmid for 48 h. FTH1 and GCH1 expression in TNBC cells was assessed by RT-qPCR and Western blotting. ( E ) CCK-8 assay detected the viability of TNBC cells transfected with shZFP64 together with FTH1 or GCH1 overexpressing plasmid in the presence of DOX. ( F ) Cell death was determined by PI staining via flow cytometry in TNBC cells transfected with shNC or shZFP64 together with FTH1 or GCH1 overexpressing plasmid in the presence of DOX. ( G - I ) MDA, Fe 2+ , and GSH levels were measured in TNBC cells transfected with shNC or shZFP64 together with FTH1 or GCH1 overexpressing plasmid in the presence of DOX. ( J ) Lipid ROS production was assessed by C11-BODIPY 581/591 probe via flow cytometry in TNBC cells transfected with shNC or shZFP64 together with FTH1 or GCH1 overexpressing plasmid in th
▸Metadata
| doi | 10.1186/s12967-025-06246-3 |
| pmcid | PMC11871786 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig5_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-23T01:08:29.187547'} |
| caption | FTH1 or GCH1 overexpression abolished shZFP64-mediated promotion in ferroptosis and DOX sensitivity in TNBC cells. ( A - D ) TNBC cells were transfected with vector, FTH1 or GCH1 overexpressing plasmi |
| paper_id | 707e4dfb-3896-4244-8e2a-7a749d45b168 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC11871786/bin/12967_2025_6246_Fig5_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 5 |
| figure_number | 5 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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