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Fig. 5 — Prolonged anesthesia induces neuroinflammation and complement-mediated microglia
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Created: 2026-04-21T18:29:40
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Fig. 5Figure 5
Prolonged anesthesia enhanced microglia phagocytosis and chemotaxis and then triggered microglial synaptic engulfment resulting in synaptic loss. A Prolonged anesthesia decreased the expression of the mRNA of synaptic markers, including SYP, SYN1, and PSD95 ( n = 3 per group). B Prolonged anesthesia increased the expression of the mRNA of complement markers, including C1qa and C3 ( n = 3 per group). C Prolonged anesthesia increased the expression of the mRNA of the microglial phagocytosis marker (CD68) ( n = 3 per group). D Prolonged anesthesia increased the expression of the microglial phagocytosis marker (CD68) at the protein level ( n = 3 per group). E Immunoblotting band of CD68, C1qa, PSD95, SYN1, SYP, and β-actin ( n = 3 per group). F Prolonged anesthesia increased the expression of C1qa. G–I Prolonged anesthesia decreased the expression of PSD95 ( G ), SYN1 ( H ), and SYP ( I ). J Prolonged anesthesia enhanced microglial phagocytosis. The iba1(green) positiv
▸Metadata
| pmid | paper-133bd96a1c04 |
| caption | Prolonged anesthesia enhanced microglia phagocytosis and chemotaxis and then triggered microglial synaptic engulfment resulting in synaptic loss. A Prolonged anesthesia decreased the expression of t |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC9814183/bin/12916_2022_2705_Fig5_HTML.jpg |
| paper_title | Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors. |
| figure_label | Fig. 5 |
| figure_number | 5 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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