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Fig. 1 — Potent and specific MTH1 inhibitors targeting gastric cancer.
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Created: 2026-04-21T18:29:40
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Fig. 1Figure 1
Characteristic expression of MTH1 in human gastric cancer tissues and ten digestive tract cancer cell lines. a The total RNA from fresh human gastric cancer tissues was isolated by RNApure Tissue&Cell Kit. The mRNA level of MTH1 in human gastric cancer (Increased, n = 21, Decreased, n = 6 and Unchanged, n = 8) and adjacent normal tissues (Con, n = 35) was determined by RT-PCR. The protein levels of MTH1 in human gastric (GC) and adjacent normal (GN) tissue sections were determined by immuohistochemistry (IHC) staining. The integral optical densities (IOD) were analyzed by Image-Pro Plus 6.0 software. b Representative IHC pictures of GC and GN. Scale bars, 50 μm. c IODs of GC and GN. n = 10 for each group. The cells from esophageal cancer cell lines: KYSE-450, EC109 and EC9706 ( d , e ), liver cancer cell lines: SMMC-7721, HepG2 and ZIP177 ( f , g ), gastric cancer cell lines: MGC-803, HGC-27, SGC-7901 and MKN45 ( h , i ), as well as the corresponding normal cell lines
▸Metadata
| pmid | paper-18d2a490986a |
| caption | Characteristic expression of MTH1 in human gastric cancer tissues and ten digestive tract cancer cell lines. a The total RNA from fresh human gastric cancer tissues was isolated by RNApure Tissue&Cel |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC6547740/bin/41419_2019_1665_Fig1_HTML.jpg |
| paper_title | Potent and specific MTH1 inhibitors targeting gastric cancer. |
| figure_label | Fig. 1 |
| figure_number | 1 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
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Outgoing
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0 contradicting
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