🖼
Figure 8 — Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis opt
active
paper figure
Created: 2026-04-21T18:29:40
By: paper_figures_tool
Quality:
50%
🔗 External
ID: paper-fig-paper-41665955-8
Figure 8Figure 8
Disease-associated microglia interact with motor neurons in an NMO mouse model. ( A ) Representative immunostained images of motor neuron–associated (ChAT + ) microglia (IBA1 + ) in ventral gray matter of mice infused for 3 days with IgG infusion. Boxed areas are enlarged on the right. 3D rendering of boxed area in AQP4-IgG mice is shown as split confocal channels (lower right) and merged (lower center). ( B and C ) Quantification of microglia-neuron co-colocalization area ( B ) and volume ( C ) in A ( n = 6 mice per group in B ; n = 1,526 and 1,272 microglial contacts, respectively, for Ctrl-IgG and AQP4-IgG mice). ( D ) ImageJ analysis shows the percentage area occupied by Galectin-3 within contacting microglia is greater than in noncontacting microglia in lumbar cord of the 2 experimental groups. ( E ) Overlaid confocal images show microglial P2Y12 receptor (yellow), Galectin-3 marker of DAMs (cyan) contacting neurons in lumbar ventral gray matter of AQP4-IgG-infused mice, i
▸Metadata
| pmid | paper-41665955 |
| caption | Disease-associated microglia interact with motor neurons in an NMO mouse model. ( A ) Representative immunostained images of motor neuron–associated (ChAT + ) microglia (IBA1 + ) in ventral gray matte |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC13038209/bin/jci-136-199706-g008.jpg |
| paper_title | Neutrophil-microglia interaction drives motor dysfunction in a neuromyelitis optica model induced by subarachnoid AQP4-IgG. |
| figure_label | Figure 8 |
| figure_number | 8 |
| _schema_version | 1 |
| source_strategy | pmc_api |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
0%
Debates
0
Incoming
0
Outgoing
1
0 supporting
0 contradicting
0 neutral
Public annotations (0)Annotate on Hypothes.is →
No public annotations yet.