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Figure 2 — HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regula
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Created: 2026-04-21T18:29:40
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Figure 2Figure 2
The cytosolic DNA sensor cGAS is activated after cerebral ischemia/reperfusion. ( A ) The mRNA level of cGAS in primary microglia isolated from brain tissue 3 h post-tMCAO (9 mice per group). ( B ) The protein level of cGAS in primary microglia isolated from brain tissue at 1, 2, 3 and 6 h post-tMCAO, respectively. The gray values were analyzed by using ImageJ and were normalized to Iba1. ( C ) BV2 cells were transfected with siRNA against cGAS and harvested 48 h post-transfection to quantify the mRNA level of cGAS. ( D ) cGAS-silenced and control BV2 cells were transfected with poly(dA:dT) and harvested 3 h post-poly(dA:dT) treatment to analyze the protein levels of pIRF3, cGAS, and GAPDH. ( E ) cGAS-silenced, STING-silenced, and control BV2 cells were transfected with poly(dA:dT) and harvested 6 h post-poly(dA:dT) treatment to analyze the mRNA level of IFN-β. ( F ) BV2 cells were transfected with siRNA against STING and harvested 48 h post-transfection to quantify the mRNA level of
▸Metadata
| pmid | paper-60585853d1d9 |
| caption | The cytosolic DNA sensor cGAS is activated after cerebral ischemia/reperfusion. ( A ) The mRNA level of cGAS in primary microglia isolated from brain tissue 3 h post-tMCAO (9 mice per group). ( B ) T |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC7449914/bin/thnov10p9644g002.jpg |
| paper_title | HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. |
| figure_label | Figure 2 |
| figure_number | 2 |
| _schema_version | 1 |
| source_strategy | pmc_api |
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