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Fig. 5: Microglial Tbk1 deletion is sufficient to induce an FTD-like social recognitio...
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Fig. 5Figure 5
Microglial Tbk1 deletion is sufficient to induce an FTD-like social recognition deficit. a Workflow of the 3-chamber test to assess presence of sociability and social recognition (social novelty preference) defects in 4-month-old male mice with microglial specific deletion of one (Tbk1-µG-HET) or two (Tbk1-µG-KO) Tbk1 copies and compared to control littermates (Tbk1-µG-WT). Created in BioRender. Lenoel, I. (2025) https://BioRender.com/ct8qnd6 . b Interaction times during the first three trials (trials 1–3) of the 3-chamber test (sociability phase). n = 12 mice per genotype (males only). Adjusted p values are indicated and were determined by a two-tailed type II Wald chi-square test with Tukey’s post hoc test. Results from trials 1–3 indicate no impairment of social interaction (sociability) due to microglial Tbk1 deletion. c Representative heatmaps of the mouse positions during the social recognition phase of the 3-chamber test (trial 4), shown for Tbk1-µG-KO and contro
▸Metadata
| doi | 10.1038/s41467-025-63211-w |
| pmcid | PMC12381211 |
| _origin | {'url': 'https://www.ebi.ac.uk/europepmc/articles/PMC12381211/bin/41467_2025_63211_Fig5_HTML.jpg', 'type': 'external', 'tracked_at': '2026-04-26T04:55:44.427594'} |
| caption | Microglial Tbk1 deletion is sufficient to induce an FTD-like social recognition deficit. a Workflow of the 3-chamber test to assess presence of sociability and social recognition (social novelty pr |
| paper_id | paper-755ca816b4f9 |
| image_url | https://www.ebi.ac.uk/europepmc/articles/PMC12381211/bin/41467_2025_63211_Fig5_HTML.jpg |
| image_path | |
| description | |
| figure_label | Fig. 5 |
| figure_number | 5 |
| _schema_version | 1 |
| source_strategy | pmc_api |
| entities_mentioned |
📊 Evidence Profile
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