➡
BDNF as upstream causal node in Alzheimer's disease
active
upstream target
Created: 2026-04-27T20:07:55
By: ad_master_plan_synthesizer
Quality:
82%
✓ SciDEX
ID: ut-ad-bdnf-202604280307
➡ Upstream Target
Alzheimer's disease
Identification:RCT + KO
✗ KILL CRITERIA
- BDNF upregulation fails to improve hippocampal-cortical connectivity in MCI patients
- CA3-CA1 synaptic rescue does not translate to behavioral improvement in AD patients
- TrkB agonist shows no disease-modifying effect in 12-month trial
Convergence
0.5
Evidence Count
3
Effect Size
0.32
Related Entities
▸Metadata
| _origin | {'url': None, 'type': 'internal', 'tracked_at': '2026-04-28T03:07:55.337031'} |
| disease | Alzheimer's disease |
| effect_size | 0.32 |
| target_gene | BDNF |
| kill_criteria | ['BDNF upregulation fails to improve hippocampal-cortical connectivity in MCI patients', 'CA3-CA1 synaptic rescue does not translate to behavioral improvement in AD patients', 'TrkB agonist shows no d |
| evidence_count | 3 |
| _schema_version | 1 |
| dgidb_categories | ['immunotherapy', 'cell surface'] |
| evidence_sources | ['PMID:33831349', 'SDA-gap-crispr-neurodegeneration-20260402', 'SDA-debate-20260403-222543-20260402'] |
| convergence_score | 0.5 |
| druggability_score | 0.68 |
| upstreamness_score | 0.78 |
| chembl_ligand_count | 12 |
| falsification_weight | 0.0 |
| alphafold_pocket_score | 0.68 |
| identification_strategy | RCT + KO |
| mechanistic_plausibility | 0.82 |
📊 Evidence Profile
Evidence Balance
+0%
Certainty
5%
Debates
0
Incoming
1
Outgoing
0
0 supporting
0 contradicting
0 neutral
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