Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons
Introduction
<table class="infobox infobox-cell">
<tr>
<th class="infobox-header" colspan="2">Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons</th>
</tr>
<tr>
<td class="label">Taxonomy</td>
<td>ID</td>
</tr>
<tr>
<td class="label">Cell Ontology (CL)</td>
<td>[CL:0000197](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000197)</td>
</tr>
<tr>
<td class="label">Database</td>
<td>ID</td>
</tr>
<tr>
<td class="label">Cell Ontology</td>
<td>[CL:0000197](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000197)</td>
</tr>
<tr>
<td class="label">Cell Ontology</td>
<td>[CL:0004117](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0004117)</td>
</tr>
<tr>
<td class="label">Receptor Type</td>
<td>nAChR α9α10</td>
</tr>
<tr>
<td class="label">Family</td>
<td>Nicotinic acetylcholine</td>
</tr>
<tr>
<td class="label">Signaling Mechanism</td>
<td>Ligand-gated ion channel, Ca2+ permeable</td>
</tr>
<tr>
<td class="label">Primary Location</td>
<td>Cochlea, vestibular system, dorsal root ganglia</td>
</tr>
</table>
[Nicotinic acetylcholine receptor](/mechanisms/cholinergic-hypothesis) (nAChR) α9α10 receptor neurons are important in the neurobiology of [Alzheimer's disease](/diseases/alzheimers-disease), [Parkinson's disease](/diseases/parkinsons-disease), and other neurodegenerative conditions. This page provides detailed information about their structure, function, and role in disease processes.
Overview
Mermaid diagram (expand to render)
Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons express the nAChR alpha9alpha10 receptor, a [ligand-gated ion channel](/proteins/nicotinic-receptors) involved in:
- [Acetylcholine](/mechanisms/cholinergic-hypothesis) signaling
- Auditory processing in the cochlea
- Pain modulation in sensory neurons
- Neuroprotection through nicotinic signaling
These receptors are unique among nicotinic receptors as they can form functional channels composed of alpha9 and alpha10 subunits. They are expressed in various brain regions including the [hippocampus](/brain-regions/hippocampus), [basal forebrain](/brain-regions/basal-ganglia), and [cochlear nucleus](/brain-regions/cochlear-nucleus).
In [neurodegenerative diseases](/diseases/alzheimers-disease), alpha9alpha10 nAChRs may represent therapeutic targets as their activation can provide neuroprotection against [excitotoxicity](/mechanisms/excitotoxicity), [oxidative stress](/mechanisms/oxidative-stress), and [neuroinflammation](/mechanisms/neuroinflammation).
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<!-- multi-taxonomy-enrichment -->
Multi-Taxonomy Classification
Taxonomy Database Cross-References
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:0000197)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000197)
- [OBO Foundry (CL:0000197)](http://purl.obolibrary.org/obo/CL_0000197)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [Human Cell Atlas](https://www.humancellatlas.org/)
- [PanglaoDB](https://panglaodb.se/)
Taxonomy & Classification
PanglaoDB Marker Cross-References
External Database Links
- [Cell Ontology (CL:0000197)](https://www.ebi.ac.uk/ols4/ontologies/cl/classes/http%253A%252F%252Fpurl.obolibrary.org%252Fobo%252FCL_0000197)
- [OBO Foundry (CL:0000197)](http://purl.obolibrary.org/obo/CL_0000197)
- [Allen Brain Cell Atlas](https://portal.brain-map.org/atlases-and-data/bkp/abc-atlas)
- [CellxGene Census](https://cellxgene.cziscience.com/)
- [PanglaoDB](https://panglaodb.se/)
Receptor Properties
Function
Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons are involved in Auditory processing, pain modulation. These neurons express the nAChR α9α10 receptor which ligand-gated ion channel, ca2+ permeable. The receptor's location in cochlea, vestibular system, dorsal root ganglia allows it to modulate neurotransmission and cellular signaling in key brain regions.
Signaling Pathway
The nAChR α9α10 receptor signals through ligand-gated ion channel, ca2+ permeable. This mechanism allows rapid or modulatory responses depending on the cellular context and co-expression of other receptors.
Disease Implications
Hearing loss, chronic pain syndromes. Understanding the role of these receptor neurons provides insight into potential therapeutic targets for these conditions.
Therapeutic Targets
The nAChR α9α10 receptor is a target for drug development in:
- Neurological disorders
- Neuropsychiatric conditions
- Neurodegenerative diseases
- Receptor Neurons
- Neurotransmitter Systemsmechanisms/cholinergic-hypothesis-ad)
- Nicotinic acetylcholine Signaling
Background
The study of Nicotinic Acetylcholine Alpha 9 Alpha 10 Receptor Neurons has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
External Links
- [PubMed](https://pubmed.ncbi.nlm.nih.gov/) - Biomedical literature
- [Alzheimer's Disease Neuroimaging Initiative](https://adni.loni.usc.edu/) - Research data
- [Allen Brain Atlas](https://brain-map.org/) - Brain gene expression data
See Also
- [Principal Pars Compacta](/wiki/cell-types-principal-pars-compacta) — associated_with
- [Principal Pars Compacta](/wiki/cell-types-principal-pars-compacta) — expressed_in
- [Principal Pars Compacta](/wiki/cell-types-principal-pars-compacta) — inhibits
- [ADAM10 — A Disintegrin And Metalloproteinase Domain 10](/wiki/genes-adam10) — inhibits
Pathway Diagram
The following diagram shows the key molecular relationships involving Nicotinic Acetylcholine Alpha-9/Alpha-10 Receptor Neurons discovered through SciDEX knowledge graph analysis:
Mermaid diagram (expand to render)