HSP90AA1 is a human gene whose product aHSA1** (Activator of Hsp90 ATPase 1), also known as Hsp90 co-chaperone AHA1, is a key co-chaperone that stimulates the ATPase activity of Hsp90. It plays a crucial role in regulating the Hsp90 chaperone cycle and thus affects the folding and function of numerous client proteins. Variants in HSP90AA1 have been implicated in Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration. [@aha2021]
HSP90AA1 is a human gene whose product aHSA1** (Activator of Hsp90 ATPase 1), also known as Hsp90 co-chaperone AHA1, is a key co-chaperone that stimulates the ATPase activity of Hsp90. It plays a crucial role in regulating the Hsp90 chaperone cycle and thus affects the folding and function of numerous client proteins. Variants in HSP90AA1 have been implicated in Alzheimer's Disease, Parkinson's Disease, Amyotrophic Lateral Sclerosis. This page covers the gene's normal function, disease associations, expression patterns, and key research findings relevant to neurodegeneration. [@aha2021]
AHSA1 (Activator of Hsp90 ATPase 1), also known as Hsp90 co-chaperone AHA1, is a key co-chaperone that stimulates the ATPase activity of Hsp90. It plays a crucial role in regulating the Hsp90 chaperone cycle and thus affects the folding and function of numerous client proteins.
Molecular Function
AHSA1 has essential co-chaperone functions:
Hsp90 ATPase activation: Stimulates Hsp90 ATP hydrolysis, accelerating the chaperone cycle
Client protein loading: Facilitates proper folding of Hsp90 client proteins
Chaperone complex assembly: Part of the Hsp90 co-chaperone network
Cellular stress response: Modulates cellular responses to proteotoxic stress
Signal transduction: Regulates signaling pathways through client protein maturation
[Unknown, Hsp90 and AHA1 in tauopathies (Journal of Alzheimer's Disease, 2019) (2019)](https://doi.org/10.3233/JAD-190234)
[Unknown, Hsp90 co-chaperones in Parkinson's disease (Molecular Neurobiology, 2020) (2020)](https://doi.org/10.1007/s12035-020-01967-6)
[Unknown, AHA1 as a therapeutic target in ALS (Neurobiology of Disease, 2021) (2021)](https://doi.org/10.1016/j.nbd.2021.105287)
[Unknown, Hsp90 AHA1: The ATPase activator (Cell Stress and Chaperones, 2018) (2018)](https://doi.org/10.1007/s12192-018-0887-0)
[Unknown, Targeting Hsp90 co-chaperones in cancer (Nature Reviews Cancer, 2017) (2017)](https://doi.org/10.1038/nrc.2017.32)
[Unknown, The Hsp90 chaperone system in neurodegeneration (Pharmacology & Therapeutics, 2020) (2020)](https://doi.org/10.1016/j.pharmthera.2020.107591)